PMID- 21150614
OWN - NLM
STAT- MEDLINE
DCOM- 20130625
LR  - 20220316
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 16
IP  - 1
DP  - 2011 Feb
TI  - iPS cells for transplantation.
PG  - 96-100
LID - 10.1097/MOT.0b013e32834252a2 [doi]
AB  - PURPOSE OF REVIEW: The induced pluripotent stem (iPS) cells from patient's 
      somatic cells could be a useful source for drug discovery and cell 
      transplantation therapies. However, there are still several problems to be solved 
      in terms of safety concerns. We herein summarize the current knowledge about iPS 
      cells and the obstacles that must be overcome before the cells can be used for 
      medical applications. RECENT FINDINGS: Recent progress has enabled us to generate 
      integration-free iPS cells from noninvasive tissues. Several studies have also 
      uncovered differences in iPS cells and ES cells in terms of gene expression, 
      epigenetic modification, and differentiation potentials. Tissue origin affects 
      the quality of iPS cells. However, in a rodent disease model, the transplantation 
      of differentiated cells derived from iPS cells ameliorated their symptoms. 
      Methods for gene correction and direct cell fate switching have also been 
      reported. The successful generation of human leukocyte antigen (HLA)-typed iPS 
      cells has been described. These findings should therefore facilitate the further 
      application of iPS cells. SUMMARY: Human iPS cells are able to provide functional 
      neuronal cells, blood cells, and retinal cells, which would be a useful source 
      for transplantation. Although recent reports have shown that it may be possible 
      to overcome several difficulties associated with iPS cells, further improvements 
      are needed, not only regarding safety aspects, but also in quality, before they 
      can be medically applied.
FAU - Okita, Keisuke
AU  - Okita K
AD  - Department of Reprogramming Science, Center for iPS Cell Research and Application 
      (CiRA), Kyoto University, Kyoto, Japan. okita@cira.kyoto-u.ac.jp
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
SB  - IM
MH  - Animals
MH  - Cell Differentiation/physiology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology/*transplantation
EDAT- 2010/12/15 06:00
MHDA- 2013/06/26 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2013/06/26 06:00 [medline]
AID - 10.1097/MOT.0b013e32834252a2 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2011 Feb;16(1):96-100. doi: 
      10.1097/MOT.0b013e32834252a2.