PMID- 21153449
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20211020
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 21
IP  - 3
DP  - 2011 Mar
TI  - Gastric bypass in the treatment of type 2 diabetes in patients with a BMI of 30 
      to 35 kg/m2.
PG  - 283-7
LID - 10.1007/s11695-010-0318-5 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) and class I obesity, which are 
      pandemics of considerable socioeconomic importance, require new treatment 
      modalities due to inadequate control through normal clinical conduct. The aim of 
      the present study was to assess the efficacy and safety of Roux-en-Y gastric 
      bypass (RYGB) in the control of T2DM in patients with a body mass index (BMI) of 
      30 to 35 kg/m(2). METHODS: An observational, retrospective study was carried out 
      at the Universidade Federal de Pernambuco-Brazil. Between 2002 and 2008, 27 
      patients were submitted to RYGB for the treatment of uncontrolled T2DM, with a 
      mean follow-up period of 20 months. An assessment was performed of the complete 
      resolution of T2DM [HbA(1c) < 6%/fasting plasma glucose (FPG) < 100 mg/dL/no 
      diabetes medication] and glycemic control. The ethics committee of the university 
      approved the study. RESULTS: RYGB led to the following results: (1) 23% weight 
      reduction (p < 0.001), BMI stabilized at 25.6 kg/m(2) in a mean of 12 months; (2) 
      46% reduction in glycemia and 27% reduction in HbA(1c) (p < 0.001); (3) 100% 
      improvement in glycemia and 48% resolution of T2DM; (4) glycemic control was 74% 
      without medication and 93% with medication and five patients required medication 
      in addition to RYGB; (5) mean current FPG is 93 mg/dL and HbA(1c) is 6%; and (6) 
      there were no severe complications or deaths. CONCLUSIONS: RYGB is a safe and 
      effective option in the treatment of uncompensated T2DM associated to class I 
      obesity.
FAU - de Sa, Vladimir Curvelo Tavares
AU  - de Sa VC
AD  - Universidade Federal de Pernambuco, Recife, Brazil. vctdesa@yahoo.com.br
FAU - Ferraz, Alvaro A
AU  - Ferraz AA
FAU - Campos, Josemberg M
AU  - Campos JM
FAU - Ramos, Almino C
AU  - Ramos AC
FAU - Araujo, Jose Guido C Jr
AU  - Araujo JG Jr
FAU - Ferraz, Edmundo M
AU  - Ferraz EM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/*epidemiology/prevention & control/*surgery
MH  - Female
MH  - *Gastric Bypass
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/*epidemiology/surgery
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Weight Loss
EDAT- 2010/12/15 06:00
MHDA- 2011/07/01 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
AID - 10.1007/s11695-010-0318-5 [doi]
PST - ppublish
SO  - Obes Surg. 2011 Mar;21(3):283-7. doi: 10.1007/s11695-010-0318-5.