PMID- 21154749
OWN - NLM
STAT- MEDLINE
DCOM- 20120913
LR  - 20211020
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 129
IP  - 8
DP  - 2011 Oct 15
TI  - Tumor necrosis factor (TNF)-alpha, soluble TNF receptors and endometrial cancer risk: 
      the EPIC study.
PG  - 2032-7
LID - 10.1002/ijc.25840 [doi]
AB  - Chronic inflammation has been hypothesized to play a role in endometrial cancer 
      development. Tumor necrosis factor-alpha (TNF-alpha), one of the major pro-inflammatory 
      cytokines, has also been implicated in endometrial physiology. We conducted a 
      case-control study nested within the European prospective investigation into 
      cancer and nutrition (EPIC) to examine the association of TNF-alpha and its two 
      soluble receptors (sTNFR1 and sTNFR2) with endometrial cancer risk. 
      Two-hundred-seventy cases and 518 matched controls were analyzed using 
      conditional logistic regression. All statistical tests were two-sided. We 
      observed an increased risk of endometrial cancer among women in the highest 
      versus lowest quartile of TNF-alpha (odds ratio [OR]: 1.73, 95% CI: 1.09-2.73, 
      P(trend) = 0.01), sTNFR1 (OR: 1.68, 95% CI: 0.99-2.86, P(trend) = 0.07) and 
      sTNFR2 (OR: 1.53, 95%CI: 0.92-2.55, P(trend) = 0.03) after adjustment for 
      body-mass-index, parity, age at menopause and previous postmenopausal hormone 
      therapy use. Further adjustments for estrogens and C-peptide had minor effect on 
      risk estimates. Our data show that elevated prediagnostic concentrations of TNF-alpha 
      and its soluble receptors are related to a higher risk of endometrial cancer, 
      particularly strong in women diagnosed within 2 years of blood donation. This is 
      the first study of its kind and therefore deserves replication in further 
      prospective studies.
CI  - Copyright (c) 2010 UICC.
FAU - Dossus, Laure
AU  - Dossus L
AD  - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 
      Heidelberg, Germany.
FAU - Becker, Susen
AU  - Becker S
FAU - Rinaldi, Sabina
AU  - Rinaldi S
FAU - Lukanova, Annekatrin
AU  - Lukanova A
FAU - Tjonneland, Anne
AU  - Tjonneland A
FAU - Olsen, Anja
AU  - Olsen A
FAU - Overvad, Kim
AU  - Overvad K
FAU - Chabbert-Buffet, Nathalie
AU  - Chabbert-Buffet N
FAU - Boutron-Ruault, Marie-Christine
AU  - Boutron-Ruault MC
FAU - Clavel-Chapelon, Francoise
AU  - Clavel-Chapelon F
FAU - Teucher, Birgit
AU  - Teucher B
FAU - Chang-Claude, Jenny
AU  - Chang-Claude J
FAU - Pischon, Tobias
AU  - Pischon T
FAU - Boeing, Heiner
AU  - Boeing H
FAU - Trichopoulou, Antonia
AU  - Trichopoulou A
FAU - Benetou, Vasiliki
AU  - Benetou V
FAU - Valanou, Elisavet
AU  - Valanou E
FAU - Palli, Domenico
AU  - Palli D
FAU - Sieri, Sabina
AU  - Sieri S
FAU - Tumino, Rosario
AU  - Tumino R
FAU - Sacerdote, Carlotta
AU  - Sacerdote C
FAU - Galasso, Rocco
AU  - Galasso R
FAU - Redondo, Maria-Luisa
AU  - Redondo ML
FAU - Bonet, Catalina Bonet
AU  - Bonet CB
FAU - Molina-Montes, Esther
AU  - Molina-Montes E
FAU - Altzibar, Jone M
AU  - Altzibar JM
FAU - Chirlaque, Maria-Dolores
AU  - Chirlaque MD
FAU - Ardanaz, Eva
AU  - Ardanaz E
FAU - Bueno-de-Mesquita, H Bas
AU  - Bueno-de-Mesquita HB
FAU - van Duijnhoven, Franzel J B
AU  - van Duijnhoven FJ
FAU - Peeters, Petra H M
AU  - Peeters PH
FAU - Onland-Moret, N Charlotte
AU  - Onland-Moret NC
FAU - Lundin, Eva
AU  - Lundin E
FAU - Idahl, Annika
AU  - Idahl A
FAU - Khaw, Kay-Tee
AU  - Khaw KT
FAU - Wareham, Nicholas
AU  - Wareham N
FAU - Allen, Naomi
AU  - Allen N
FAU - Romieu, Isabelle
AU  - Romieu I
FAU - Fedirko, Veronika
AU  - Fedirko V
FAU - Hainaut, Pierre
AU  - Hainaut P
FAU - Romaguera, Dora
AU  - Romaguera D
FAU - Norat, Teresa
AU  - Norat T
FAU - Riboli, Elio
AU  - Riboli E
FAU - Kaaks, Rudolf
AU  - Kaaks R
LA  - eng
GR  - G0401527/MRC_/Medical Research Council/United Kingdom
GR  - G1000143/MRC_/Medical Research Council/United Kingdom
GR  - MC_U106179471/MRC_/Medical Research Council/United Kingdom
GR  - CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110308
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Endometrial Neoplasms/*blood
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Receptors, Tumor Necrosis Factor/*blood
MH  - Risk
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2010/12/15 06:00
MHDA- 2012/09/14 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/09/06 00:00 [received]
PHST- 2010/10/27 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2012/09/14 06:00 [medline]
AID - 10.1002/ijc.25840 [doi]
PST - ppublish
SO  - Int J Cancer. 2011 Oct 15;129(8):2032-7. doi: 10.1002/ijc.25840. Epub 2011 Mar 8.