PMID- 21155410
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20101215
IS  - 1121-2233 (Print)
IS  - 1121-2233 (Linking)
VI  - 51
IP  - 2
DP  - 2010 Jun
TI  - Hospital-acquired infections and leading pathogens detected in a regional 
      university adult acute-care hospital in Genoa, Liguria, Italy: results from a 
      prevalence study.
PG  - 80-6
AB  - BACKGROUND: A prevalence study aimed to update the epidemiological scenario of 
      Hospital-Acquired Infections (HAI) was performed at the San Martino University 
      Hospital of Genoa, the Regional Reference Adult-care Center in Liguria, Italy, 
      with more than 1300 beds. MATERIALS AND METHODS: The investigation was performed 
      in all the wards, except the Psychiatric Units, between 19th March and 6Ih April, 
      2007, using a one-day monitoring system for each ward. International standardized 
      criteria and definitions for the surveillance of HAI were used for the collection 
      of data, which were recorded in specific software for subsequent consolidation, 
      analysis and quality control. RESULTS: The hospital infection control staff 
      actively monitored 912 inpatients: a total of 84 HAI among 72 patients were 
      diagnosed, with an overall prevalence of infections and affected cases of 9.2% 
      (95% CI: 7.3-11.1) and 7.9% (95% CI: 6.1-9.7), respectively. Urinary Tract 
      Infections (UTI) (30.9%), Respiratory Tract Infections (RTI) (28.6%) and Blood 
      Stream Infections (BSI) (21.4%) were found to be the most frequent infections. As 
      expected, both specific prevalence and localization of HAI varied considerably 
      between wards, with the highest values recorded in Intensive Care Units (ICU) and 
      in Functional Rehabilitation wards. RTI (26.3%) and BSI (13.2%) were found 
      primarily represented in ICU, while the highest values of UTI (13.3%) were 
      registered in Functional Rehabilitation Units. Enterococcus spp. (16.8%), Candida 
      spp. (14%), Pseudomonas spp. (12.2), Staphylococcus aureus (10.7%), Escherichia 
      coli (10.3%) and Coagulase-negative staphylococci (CNS) (9.3%) were the most 
      frequent pathogens isolated. The overall rate of administration of antibiotics 
      was 55.3% and penicillin (26.7%), cephalosporins (22.8%) and fluoroquinolones 
      (17.9%) were found to be the leading antibacterial administered. CONCLUSION: 
      Results of the present study have been, and are currently, used for orientating 
      surveillance and control hospital policies, planning activities according to a 
      rational and evidence-based approach.
FAU - Durando, P
AU  - Durando P
AD  - Department of Health Sciences, Section of Hygiene and Preventive Medicine, 
      University of Genoa and San Martino University Hospital of Genoa, Italy. 
      durando@unige.it
FAU - Bassetti, M
AU  - Bassetti M
FAU - Orengo, G
AU  - Orengo G
FAU - Crimi, P
AU  - Crimi P
FAU - Battistini, A
AU  - Battistini A
FAU - Tiberio, G
AU  - Tiberio G
FAU - Bellina, D
AU  - Bellina D
FAU - Talamini, A
AU  - Talamini A
FAU - Dodi, F
AU  - Dodi F
FAU - Ansaldi, F
AU  - Ansaldi F
FAU - Alicino, C
AU  - Alicino C
FAU - Iudici, R
AU  - Iudici R
FAU - Sticchi, L
AU  - Sticchi L
FAU - De Florentiis, D
AU  - De Florentiis D
FAU - Viscoli, C
AU  - Viscoli C
FAU - Icardi, G
AU  - Icardi G
CN  - Prevalence Study Working Group of the San Martino University Hospital of Genoa
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Prev Med Hyg
JT  - Journal of preventive medicine and hygiene
JID - 9214440
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bacteremia/epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Cross Infection/*epidemiology/prevention & control
MH  - Female
MH  - Gram-Negative Bacteria/classification/*isolation & purification
MH  - Gram-Negative Bacterial Infections/*epidemiology/prevention & control
MH  - Gram-Positive Bacteria/classification/*isolation & purification
MH  - Gram-Positive Bacterial Infections/*epidemiology/prevention & control
MH  - Hospitals, Public/organization & administration
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infection Control/*organization & administration
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - Pneumonia/epidemiology
MH  - Prevalence
MH  - Sepsis/epidemiology
MH  - Surgical Wound Infection/epidemiology
MH  - Urinary Tract Infections/epidemiology
MH  - Young Adult
EDAT- 2010/12/16 06:00
MHDA- 2011/01/11 06:00
CRDT- 2010/12/16 06:00
PHST- 2010/12/16 06:00 [entrez]
PHST- 2010/12/16 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
PST - ppublish
SO  - J Prev Med Hyg. 2010 Jun;51(2):80-6.