PMID- 21156193
OWN - NLM
STAT- MEDLINE
DCOM- 20110818
LR  - 20110214
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 3
DP  - 2011 Mar
TI  - Natural killer cell receptor expression reflects the role of human 
      cytomegalovirus in the pathogenesis of a subset of CD4+ T-cell large granular 
      lymphocytosis.
PG  - 226-8
LID - 10.1016/j.humimm.2010.12.006 [doi]
AB  - A high frequency of CD4(+) T-cell large granular lymphocyte (T-LGL) lymphocytosis 
      occurs in human leukocyte antigen (HLA) -DRB1*0701 individuals displaying 
      monoclonal expansions of Vbeta13.1+ CD4(+) T-cell clones, which specifically respond 
      to human cytomegalovirus (HCMV) antigens. We previously reported the expression 
      of natural killer (NK)-cell associated receptors (NKR) by HCMV-specific cytolytic 
      CD4(+) T cells from healthy donors. In the present study a high expression of 
      different NKR (i.e., NKG2D, killer Ig-like receptors (KIR), CD94, ILT2) was 
      observed in CD4(+) T cells from both Vbeta13.1- and Vbeta13.1+ CD4(+) T-LGL cases. 
      Remarkably, elevated numbers of CD94/NKG2C+ NK cells, previously shown to expand 
      in association to HCMV infection, were preferentially found in Vbeta13.1+ T-LGL, 
      further supporting its role in the pathogenesis of a subset of CD4(+) T-LGL.
CI  - Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Saez-Borderias, Andrea
AU  - Saez-Borderias A
AD  - Molecular Immunopathology Unit, Universitat Pompeu Fabra (DCEXS), Barcelona, 
      Spain.
FAU - Romo, Neus
AU  - Romo N
FAU - Ruiz-Cabello, Francisco
AU  - Ruiz-Cabello F
FAU - Canton, Julia
AU  - Canton J
FAU - Tielemans, Dennis
AU  - Tielemans D
FAU - Langerak, Anton W
AU  - Langerak AW
FAU - Lopez-Botet, Miguel
AU  - Lopez-Botet M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101213
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Receptors, Natural Killer Cell)
SB  - IM
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Cytomegalovirus/*immunology
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - *Lymphocytosis
MH  - Natural Killer T-Cells/*immunology
MH  - Polymerase Chain Reaction
MH  - Receptors, Natural Killer Cell/*genetics/*immunology
EDAT- 2010/12/16 06:00
MHDA- 2011/08/19 06:00
CRDT- 2010/12/16 06:00
PHST- 2010/06/15 00:00 [received]
PHST- 2010/11/20 00:00 [revised]
PHST- 2010/12/06 00:00 [accepted]
PHST- 2010/12/16 06:00 [entrez]
PHST- 2010/12/16 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - S0198-8859(10)00569-0 [pii]
AID - 10.1016/j.humimm.2010.12.006 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Mar;72(3):226-8. doi: 10.1016/j.humimm.2010.12.006. Epub 2010 
      Dec 13.