PMID- 21156244
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20121030
IS  - 1873-4456 (Electronic)
IS  - 0165-4608 (Linking)
VI  - 203
IP  - 2
DP  - 2010 Dec
TI  - FISH-negative cryptic PML-RARA rearrangement detected by long-distance polymerase 
      chain reaction and sequencing analyses: a case study and review of the 
      literature.
PG  - 278-83
LID - 10.1016/j.cancergencyto.2010.08.026 [doi]
AB  - Although a normal karyotype according to conventional cytogenetic analysis in 
      association with cryptic t(15;17) has been infrequently reported in cases of 
      acute promyelocytic leukemia (APL), a fluorescence in situ hybridization 
      (FISH)-negative cryptic PML-RARA rearrangement is even more rare, with only 12 
      such APL cases of FISH-negative cryptic PML-RARA rearrangements in the 
      literature. Reported here is an additional clinical APL case with a FISH-negative 
      cryptic PML-RARA rearrangement, confirmed by long-distance DNA polymerase chain 
      reaction method. Discussion includes a relevant literature review of similar 
      cases. DNA-PCR can be a useful tool for the analysis of complex and cryptic 
      rearrangements.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Kim, Min Jin
AU  - Kim MJ
AD  - Department of Laboratory Medicine, School of Medicine, Kyung Hee University, 1 
      Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Korea.
FAU - Cho, Sun Young
AU  - Cho SY
FAU - Kim, Myeong-Hee
AU  - Kim MH
FAU - Lee, Jae Jin
AU  - Lee JJ
FAU - Kang, So Young
AU  - Kang SY
FAU - Cho, Eun Hae
AU  - Cho EH
FAU - Huh, Jungwon
AU  - Huh J
FAU - Yoon, Hwi-Joong
AU  - Yoon HJ
FAU - Park, Tae Sung
AU  - Park TS
FAU - Lee, Woo-In
AU  - Lee WI
FAU - Marschalek, Rolf
AU  - Marschalek R
FAU - Meyer, Claus
AU  - Meyer C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein)
SB  - IM
CIN - Ann Hematol. 2012 Oct;91(10):1645-8. PMID: 22402611
MH  - Adolescent
MH  - Adult
MH  - Chromosomes/ultrastructure
MH  - *Cytogenetics
MH  - Female
MH  - *Gene Rearrangement
MH  - Genome, Human
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Polymerase Chain Reaction/*methods
MH  - Reverse Transcriptase Polymerase Chain Reaction/methods
MH  - Sequence Analysis, DNA/*methods
EDAT- 2010/12/16 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/12/16 06:00
PHST- 2010/08/02 00:00 [received]
PHST- 2010/08/24 00:00 [revised]
PHST- 2010/08/28 00:00 [accepted]
PHST- 2010/12/16 06:00 [entrez]
PHST- 2010/12/16 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - S0165-4608(10)00489-9 [pii]
AID - 10.1016/j.cancergencyto.2010.08.026 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2010 Dec;203(2):278-83. doi: 
      10.1016/j.cancergencyto.2010.08.026.