PMID- 21156273
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20131121
IS  - 1527-5418 (Electronic)
IS  - 0890-8567 (Linking)
VI  - 50
IP  - 1
DP  - 2011 Jan
TI  - Lower N-acetyl-aspartate levels in prefrontal cortices in pediatric bipolar 
      disorder: a (1)H magnetic resonance spectroscopy study.
PG  - 85-94
LID - 10.1016/j.jaac.2010.10.007 [doi]
AB  - OBJECTIVE: The few studies applying single-voxel (1)H spectroscopy in children and 
      adolescents with bipolar disorder (BD) have reported low N-acetyl-aspartate (NAA) 
      levels in the dorsolateral prefrontal cortex (DLPFC), and high myo-inositol / 
      phosphocreatine plus creatine (PCr+Cr) ratios in the anterior cingulate. The aim 
      of this study was to evaluate NAA, glycerophosphocholine plus phosphocholine 
      (GPC+PC) and PCr+Cr in various frontal cortical areas in children and adolescents 
      with BD. We hypothesized that NAA levels within the prefrontal cortex are lower 
      in BD patients than in healthy controls, indicating neurodevelopmental 
      alterations in the former. METHOD: We studied 43 pediatric patients with DSM-IV 
      BD (19 female, mean age 13.2 +/- 2.9 years) and 38 healthy controls (19 female, 
      mean age 13.9 +/- 2.7 years). We conducted multivoxel in vivo (1)H spectroscopy 
      measurements at 1.5 Tesla using a long echo time of 272 ms to obtain bilateral 
      metabolite levels from the medial prefrontal cortex (MPFC), DLPFC (white and gray 
      matter), cingulate (anterior and posterior), and occipital lobes. We used the 
      nonparametric Mann-Whitney U test to compare neurochemical levels between groups. 
      RESULTS: In pediatric BD patients, NAA and GPC+PC levels in the bilateral MPFC, 
      and PCr+Cr levels in the left MPFC were lower than those seen in the controls. In 
      the left DLPFC white matter, levels of NAA and PCr+Cr were also lower in BD 
      patients than in controls. CONCLUSIONS: Lower NAA and PCr+Cr levels in the PFC of 
      children and adolescents with BD may be indicative of abnormal dendritic 
      arborization and neuropil, suggesting neurodevelopmental abnormalities.
CI  - Copyright (c) 2011 American Academy of Child and Adolescent Psychiatry. Published 
      by Elsevier Inc. All rights reserved.
FAU - Caetano, Sheila C
AU  - Caetano SC
AD  - University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
FAU - Olvera, Rene L
AU  - Olvera RL
FAU - Hatch, John P
AU  - Hatch JP
FAU - Sanches, Marsal
AU  - Sanches M
FAU - Chen, Hua Hsuan
AU  - Chen HH
FAU - Nicoletti, Mark
AU  - Nicoletti M
FAU - Stanley, Jeffrey A
AU  - Stanley JA
FAU - Fonseca, Manoela
AU  - Fonseca M
FAU - Hunter, Kristina
AU  - Hunter K
FAU - Lafer, Beny
AU  - Lafer B
FAU - Pliszka, Steven R
AU  - Pliszka SR
FAU - Soares, Jair C
AU  - Soares JC
LA  - eng
GR  - M01-RR-01346/RR/NCRR NIH HHS/United States
GR  - MH 01736/MH/NIMH NIH HHS/United States
GR  - MH 068662/MH/NIMH NIH HHS/United States
GR  - MH 69774/MH/NIMH NIH HHS/United States
GR  - RR 020571/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101125
PL  - United States
TA  - J Am Acad Child Adolesc Psychiatry
JT  - Journal of the American Academy of Child and Adolescent Psychiatry
JID - 8704565
RN  - 0 (Protons)
RN  - 020IUV4N33 (Phosphocreatine)
RN  - 107-73-3 (Phosphorylcholine)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 4L6452S749 (Inositol)
RN  - 60M22SGW66 (Glycerylphosphorylcholine)
RN  - 997-55-7 (N-acetylaspartate)
SB  - IM
MH  - Adolescent
MH  - Aspartic Acid/*analogs & derivatives/chemistry/metabolism
MH  - Bipolar Disorder/diagnosis/*metabolism/physiopathology
MH  - *Brain Chemistry
MH  - Child
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Glycerylphosphorylcholine/chemistry/metabolism
MH  - Humans
MH  - Inositol/chemistry/metabolism
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Phosphocreatine/chemistry/metabolism
MH  - Phosphorylcholine/chemistry/metabolism
MH  - Prefrontal Cortex/chemistry/*growth & development
MH  - *Protons
EDAT- 2010/12/16 06:00
MHDA- 2011/04/20 06:00
CRDT- 2010/12/16 06:00
PHST- 2009/11/13 00:00 [received]
PHST- 2010/10/15 00:00 [revised]
PHST- 2010/10/19 00:00 [accepted]
PHST- 2010/12/16 06:00 [entrez]
PHST- 2010/12/16 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - S0890-8567(10)00784-7 [pii]
AID - 10.1016/j.jaac.2010.10.007 [doi]
PST - ppublish
SO  - J Am Acad Child Adolesc Psychiatry. 2011 Jan;50(1):85-94. doi: 
      10.1016/j.jaac.2010.10.007. Epub 2010 Nov 25.