PMID- 21156398 OWN - NLM STAT- MEDLINE DCOM- 20110613 LR - 20211020 IS - 1552-9924 (Electronic) IS - 0091-6765 (Print) IS - 0091-6765 (Linking) VI - 119 IP - 3 DP - 2011 Mar TI - Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in obese subjects before and after drastic weight loss. PG - 377-83 LID - 10.1289/ehp.1002848 [doi] AB - BACKGROUND: In humans, persistent organic pollutants (POPs) are stored primarily in adipose tissue. Their total body burden and their contribution to obesity-associated diseases remain unclear. OBJECTIVES: We characterized POP total body burden and their redistribution in obese individuals before and after drastic weight loss and compared these values with a variety of molecular, biological, and clinical parameters. METHODS: Seventy-one obese subjects were enrolled and underwent bariatric surgery. Blood and adipose tissue samples were obtained at different times from these individuals as well as from 18 lean women. RESULTS: POP content (17 dioxins/furans and 18 polychlorinated biphenyl congeners) in different adipose tissue territories was similar, allowing us to assess total POP body burden from a single biopsy. Total POP body burden was 2 to 3 times higher in obese than in lean individuals. We also found increased expression of some POP target genes in obese adipose tissue. Drastic weight loss led to increased serum POPs and, within 6-12 months, to a significant 15% decrease in total polychlorinated biphenyl body burden. Importantly, serum POP levels were positively correlated with liver toxicity markers and lipid parameters, independently of age and body mass index. CONCLUSIONS: POP content in adipose tissue and serum correlate with biological markers of obesity-related dysfunctions. Drastic weight loss leads to a redistribution of POPs and to a moderate decrease of their total body burden. FAU - Kim, Min-Ji AU - Kim MJ AD - INSERM, UMR-S, Universite Paris Descartes, Centre Universitaire des Saints-Peres, France. FAU - Marchand, Philippe AU - Marchand P FAU - Henegar, Corneliu AU - Henegar C FAU - Antignac, Jean-Philippe AU - Antignac JP FAU - Alili, Rohia AU - Alili R FAU - Poitou, Christine AU - Poitou C FAU - Bouillot, Jean-Luc AU - Bouillot JL FAU - Basdevant, Arnaud AU - Basdevant A FAU - Le Bizec, Bruno AU - Le Bizec B FAU - Barouki, Robert AU - Barouki R FAU - Clement, Karine AU - Clement K LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20101215 PL - United States TA - Environ Health Perspect JT - Environmental health perspectives JID - 0330411 RN - 0 (Dioxins) RN - 0 (Environmental Pollutants) RN - DFC2HB4I0K (Polychlorinated Biphenyls) RN - EC 1.14.14.1 (Aryl Hydrocarbon Hydroxylases) RN - EC 1.14.14.1 (CYP1B1 protein, human) RN - EC 1.14.14.1 (Cytochrome P-450 CYP1A1) RN - EC 1.14.14.1 (Cytochrome P-450 CYP1B1) RN - EC 1.6.5.2 (NAD(P)H Dehydrogenase (Quinone)) RN - EC 1.6.5.2 (NQO1 protein, human) SB - IM MH - Adipose Tissue/metabolism MH - Adult MH - Aryl Hydrocarbon Hydroxylases/genetics/metabolism MH - Body Burden MH - Cytochrome P-450 CYP1A1/*metabolism MH - Cytochrome P-450 CYP1B1 MH - Dioxins/metabolism/*toxicity MH - Environmental Pollutants/metabolism/*toxicity MH - Female MH - Humans MH - Male MH - Middle Aged MH - NAD(P)H Dehydrogenase (Quinone)/genetics/metabolism MH - Obesity/blood/*metabolism/pathology MH - Polychlorinated Biphenyls/metabolism/*toxicity MH - *Weight Loss PMC - PMC3060002 EDAT- 2010/12/16 06:00 MHDA- 2011/06/15 06:00 PMCR- 2011/03/01 CRDT- 2010/12/16 06:00 PHST- 2010/08/10 00:00 [received] PHST- 2010/12/03 00:00 [accepted] PHST- 2010/12/16 06:00 [entrez] PHST- 2010/12/16 06:00 [pubmed] PHST- 2011/06/15 06:00 [medline] PHST- 2011/03/01 00:00 [pmc-release] AID - ehp-119-377 [pii] AID - 10.1289/ehp.1002848 [doi] PST - ppublish SO - Environ Health Perspect. 2011 Mar;119(3):377-83. doi: 10.1289/ehp.1002848. Epub 2010 Dec 15.