PMID- 21159243
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20211020
IS  - 1999-6187 (Electronic)
IS  - 1009-3419 (Print)
IS  - 1009-3419 (Linking)
VI  - 13
IP  - 12
DP  - 2010 Dec
TI  - [The expressions of IL-7 and IL-7R and the relationship between them with lymph 
      node metastasis and prognosis in non-small cell lung cancer].
PG  - 1101-6
LID - 10.3779/j.issn.1009-3419.2010.12.04 [doi]
AB  - BACKGROUND AND OBJECTIVE: it has been proven that lymph node metastasis was 
      closely related to prognosis of lung cancer. Interleukin-7 (IL-7) and 
      interleukin-7 receptor (IL-7R) could promote lymph node metastasis through 
      vascular endothelial growth factor-D (VEGF-D). The aim of this study is to 
      explore the expressions of IL-7 and IL-7R in lung cancer and the relationship 
      between them with lymph node metastasis and prognosis in non-small cell lung 
      cancer (NSCLC). METHODS: the expressions of IL-7 and IL-7R in 95 cases of NSCLC 
      were detected with immunohistochemistry method and the relationship between IL-7 
      and IL-7R and their impact on lung cancer patients' outcomes were analyzed. 
      RESULTS: in 95 cases of NSCLC, the high expression rates of IL-7, IL-7R and 
      VEGF-D were 63.16%, 61.05% and 58.95%. The expressions of IL-7 and IL-7R were 
      correlated closely with clinic stage and lymph node metastasis, but had no 
      relationship with age, gender, histological type and differentiation degree. The 
      lymphatic vessel density (LVD) mean of the group with high expressions of IL-7 
      and IL-7R was higher than that with low or negative expressions of IL-7 and 
      IL-7R, and they were significant different in statistics. Log-rank analysis 
      showed that the postoperative survival period was significantly shorter in high 
      expression groups IL-7, IL-7R and VEGF-D comparing with that in low or negative 
      groups. CONCLUSIONS: the high expression of IL-7 and IL-7R is highly positie 
      correlated with clinic stage, lymph node metastasis, VEGF-D, LVD and poor 
      prognosis in Non-small cell lung cancer.
FAU - MING, Jian
AU  - MING J
AD  - No.202 Hospital of People Liberation Army of China, 110003 Shenyang, China.
FAU - ZHANG, Qingfu
AU  - ZHANG Q
FAU - JIANG, Yanduo
AU  - JIANG Y
FAU - QIU, Xueshan
AU  - QIU X
FAU - BAI, Xiaozhong
AU  - BAI X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Fei Ai Za Zhi
JT  - Zhongguo fei ai za zhi = Chinese journal of lung cancer
JID - 101126433
RN  - 0 (Interleukin-7)
RN  - 0 (Receptors, Interleukin-7)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/*complications/*metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Vitro Techniques
MH  - Interleukin-7/*metabolism
MH  - Lymphatic Metastasis/*pathology
MH  - Male
MH  - Middle Aged
MH  - Receptors, Interleukin-7/*metabolism
PMC - PMC6000624
EDAT- 2010/12/17 06:00
MHDA- 2011/04/09 06:00
PMCR- 2010/12/20
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
PHST- 2010/12/20 00:00 [pmc-release]
AID - zgfazz-13-12-1101 [pii]
AID - 10.3779/j.issn.1009-3419.2010.12.04 [doi]
PST - ppublish
SO  - Zhongguo Fei Ai Za Zhi. 2010 Dec;13(12):1101-6. doi: 
      10.3779/j.issn.1009-3419.2010.12.04.