PMID- 21161353
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20220318
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 34
IP  - 6
DP  - 2011 Dec
TI  - Study of programmed cell death 1 (PDCD1) gene polymorphims in Iranian patients 
      with ankylosing spondylitis.
PG  - 707-12
LID - 10.1007/s10753-010-9282-4 [doi]
AB  - Ankylosing spondylitis (AS) is a chronic inflammatory disease, characterized by 
      axial arthritis in which the genetic-environmental factors seem to be involved in 
      the pathogenesis of the disease. This study was performed to investigate the role 
      of polymorphisms of the programmed cell death 1 (PDCD1) gene on susceptibility to 
      AS. In this study, 161 Iranian patients with AS and 208 normal controls were 
      enrolled; two single-nucleotide polymorphisms (SNPs) of the PDCD1 gene PD-1.3 (G, 
      A) in nucleotide position +7146 of intron 4 and PD-1.9 (C, T) in nucleotide +7625 
      of exon 5 were studied. Analysis of PD-1.3 revealed that 82% of patients and 79% 
      of controls had GG genotype, while GA and AA genotypes were detected in 17% and 
      0.6% of patients, respectively, and 20% and 1.4% of controls, respectively. 
      Moreover, the genotype CC (PD-1.9) was present in 92% of patients and 97% of 
      controls. Although these differences were not statistically significant between 
      patients and controls, comparisons of genotypes frequencies in the AS patients, 
      based on human leukocyte antigen (HLA)-B27, revealed that all patients who had CT 
      genotype (PD-1.9) were HLA-B27 positive, whereas 30% of patients with CC genotype 
      were HLA-B27 negative. There was no evidence of association for PDCD1 SNPs with 
      AS in our study, but CT genotype (PD-1.9) seems to be associated with HLA-B27 
      positivity in the patients with AS.
FAU - Soleimanifar, Narjes
AU  - Soleimanifar N
AD  - Molecular Immunology Research Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Amirzargar, Ali Akbar
AU  - Amirzargar AA
FAU - Mahmoudi, Mahdi
AU  - Mahmoudi M
FAU - Pourfathollah, Ali Akbar
AU  - Pourfathollah AA
FAU - Azizi, Esfandiar
AU  - Azizi E
FAU - Jamshidi, Ahmad Reza
AU  - Jamshidi AR
FAU - Rezaei, Nima
AU  - Rezaei N
FAU - Tahoori, Mohammad Taher
AU  - Tahoori MT
FAU - Bidad, Katayoon
AU  - Bidad K
FAU - Nikbin, Behrouz
AU  - Nikbin B
FAU - Nicknam, Mohammad Hossein
AU  - Nicknam MH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (PDCD1 protein, human)
RN  - 0 (Programmed Cell Death 1 Receptor)
SB  - IM
MH  - Case-Control Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-B27 Antigen
MH  - Humans
MH  - Iran/epidemiology
MH  - *Polymorphism, Single Nucleotide
MH  - Programmed Cell Death 1 Receptor/*genetics
MH  - Spondylitis, Ankylosing/epidemiology/*genetics
EDAT- 2010/12/17 06:00
MHDA- 2012/06/05 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
AID - 10.1007/s10753-010-9282-4 [doi]
PST - ppublish
SO  - Inflammation. 2011 Dec;34(6):707-12. doi: 10.1007/s10753-010-9282-4.