PMID- 21161391
OWN - NLM
STAT- MEDLINE
DCOM- 20120217
LR  - 20211020
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 38
IP  - 8
DP  - 2011 Nov
TI  - Association between the IL7R T244I polymorphism and multiple sclerosis: a 
      meta-analysis.
PG  - 5079-84
LID - 10.1007/s11033-010-0654-5 [doi]
AB  - Previously published analyses of the association between the interleukin 7 
      receptor (IL7R) T244I polymorphism (rs6897932) and multiple sclerosis (MS) have 
      yielded conflicting results. We performed a meta-analysis to assess whether the 
      combined data showed this association, and to investigate its effect size. We 
      analyzed 10 studies identified from PubMed (12,185 MS patients and 15,855 
      controls) and calculated the odds ratios (ORs) and 95% confidence intervals (CIs) 
      for the C-allele, the C/C genotype (recessive effect) and the C/C + C/T (dominant 
      effect) genotype. Heterogeneity within and between studies was observed: allele 
      C: Q = 30.86, P = 0.002; genotype C/C: Q = 30.28, P = 0.003. Using a 
      random-effects model, the C-allele and the C/C genotype were associated with MS 
      (OR = 1.11, 95% CI = 1.04-1.19, P = 0.001 for the C-allele; OR = 1.15, 95% CI = 
      1.06-1.24, P = 0.0009 for the C/C genotype). The C/C + C/T genotype was also 
      associated with MS using a fixed-effects model (OR = 1.15, 95% CI = 1.05-1.26, P 
      = 0.003). There was no significant publication bias among the selected studies 
      according to the funnel plot. We also performed the analysis on a European 
      subgroup. This revealed an association between IL7R T244I and MS (P < 0.00001 for 
      the C-allele and the C/C genotype; P = 0.0004 for the C/C + C/T genotype), no 
      heterogeneity was observed (allele C: P = 0.07; genotype C/C: P = 0.10). In 
      conclusion, the meta-analysis demonstrated that the IL7R T244I polymorphism was 
      associated with susceptibility to MS.
FAU - Zhang, Ruijie
AU  - Zhang R
AD  - College of Bioinformatics Science and Technology, Harbin Medical University, 
      Harbin 150086, China. zhangruijie2009@yahoo.com.cn
FAU - Duan, Lian
AU  - Duan L
FAU - Jiang, Yongshuai
AU  - Jiang Y
FAU - Zhang, Xuehong
AU  - Zhang X
FAU - Sun, Peng
AU  - Sun P
FAU - Li, Jin
AU  - Li J
FAU - Zhang, Mingming
AU  - Zhang M
FAU - Tang, Guoping
AU  - Tang G
FAU - Wang, Xing
AU  - Wang X
FAU - Li, Xia
AU  - Li X
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20101216
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Receptors, Interleukin-7)
SB  - IM
MH  - Alleles
MH  - Amino Acid Substitution/*genetics
MH  - Confidence Intervals
MH  - Databases, Genetic
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Multiple Sclerosis/*genetics
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Receptors, Interleukin-7/*genetics
EDAT- 2010/12/17 06:00
MHDA- 2012/02/18 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/06/30 00:00 [received]
PHST- 2010/12/04 00:00 [accepted]
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - 10.1007/s11033-010-0654-5 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2011 Nov;38(8):5079-84. doi: 10.1007/s11033-010-0654-5. Epub 2010 
      Dec 16.