PMID- 21162898
OWN - NLM
STAT- MEDLINE
DCOM- 20110728
LR  - 20101217
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 90
IP  - 38
DP  - 2010 Oct 19
TI  - [Adrenal lesions in patients of multiple endocrine neoplasia type 1].
PG  - 2689-92
AB  - OBJECTIVE: To investigate the prevalence and characteristics of adrenal lesions 
      in Chinese multiple endocrine neoplasia type 1 (MEN-1) patients. METHODS: Adrenal 
      CT scan and clinical manifestations were retrospectively reviewed in 32 
      consecutive MEN-1 patients who were evaluated at our hospital during January 1986 
      to December 2009. RESULTS: Adrenal lesions were identified in 16 of 32 (50%) 
      MEN-1 patients. Five (31.3%) patents with adrenal involvement showed bilateral 
      lesions, including bilateral adenoma (n=1), bilateral hyperplasia (n=2) and 
      adenoma and hyperplasia on each side (n=2). Unilateral adrenal lesion was 
      presented in 11 (68.7%) patients. Among which, 63.6% had adenomas with a mean 
      diameter of 2.3 cm (0.8-4.0 cm) and the remainder was of hyperplasia or 
      enlargement. In two patients, functioning adrenal abnormalities were detected 
      including Cushing adenoma (n=1) and aldosterone-secreting adenoma (n=1). 
      CONCLUSIONS: The prevalence of adrenal lesion in MEN-1 patient is similar between 
      China and western countries. These tumors are mostly benign, small and 
      nonfunctioning. Taking into account a high incidence of adrenal carcinoma in 
      previous foreign studies, routine screening and close surveillance are still 
      recommended for adrenal lesions in MEN-1 patients.
FAU - Zhu, Yan
AU  - Zhu Y
AD  - Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, 
      Peking Union Medical College Hospital, Peking Union Medical College and Chinese 
      Academy of Medical Sciences, Beijing 100730, China.
FAU - Zhang, Hua-bing
AU  - Zhang HB
FAU - Lu, Lin
AU  - Lu L
FAU - Li, Nai-shi
AU  - Li NS
FAU - Fu, Yong
AU  - Fu Y
FAU - Wang, Ou
AU  - Wang O
FAU - Xu, Ling-ling
AU  - Xu LL
FAU - Jiang, Yan
AU  - Jiang Y
FAU - Tong, An-li
AU  - Tong AL
FAU - Zhu, Hui-juan
AU  - Zhu HJ
FAU - Li, Wei
AU  - Li W
FAU - Hu, Ming-ming
AU  - Hu MM
FAU - Yu, Miao
AU  - Yu M
FAU - Mao, Jiang-feng
AU  - Mao JF
FAU - Yuan, Tao
AU  - Yuan T
FAU - Li, Mei
AU  - Li M
FAU - Xia, Wei-bo
AU  - Xia WB
FAU - Xing, Xiao-ping
AU  - Xing XP
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Adrenal Glands/*pathology
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/diagnosis/*pathology
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2010/12/18 06:00
MHDA- 2011/07/29 06:00
CRDT- 2010/12/18 06:00
PHST- 2010/12/18 06:00 [entrez]
PHST- 2010/12/18 06:00 [pubmed]
PHST- 2011/07/29 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2010 Oct 19;90(38):2689-92.