PMID- 21163133
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20131121
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 123
IP  - 22
DP  - 2010 Nov
TI  - Treatment of retinal vein occlusion in rabbits with traditional Chinese medicine 
      Fufang XueShuan Tong.
PG  - 3293-8
AB  - BACKGROUND: Retinal vein occlusion (RVO) is one of the most common causes of 
      visual loss. Many approaches have been tried to treat central retinal vein 
      occlusion (CRVO), and branch retinal vein occlusion (BRVO) with various results. 
      However, there is no defined protocol and limited evidence to support the 
      interventions currently used. The aim of this study was to assess the efficacy of 
      the traditional Chinese medicine Fufang XueShuan Tong (FXST) in treating 
      experimentally created RVO. METHODS: RVO model was first induced in forty-four 
      pigmented rabbits through photocoagulation following injection of rose Bengal. 
      The rabbits were divided into four groups based on the dose of FXST administered 
      (212 mg/kg, 424 mg/kg, 848 mg/kg and control group). The rabbits were observed 
      for four weeks after the procedure, using color fundus photography, fundus 
      fluorescein angiography and electroretinogram examination. Vascular endothelial 
      growth factor (VEGF), interleukin-6 and nitric oxide (NO) levels in the vitreous 
      and histopathologic evaluation were monitored. RESULTS: The obstructed vessels in 
      the treatment groups reopened or anastomosed faster than those in the control 
      group (P < 0.05). The amplitude of maximum b wave and the oscillatory potential 
      were significantly higher in the treatment groups than in the control group (P < 
      0.01). At both two weeks and four weeks, VEGF and IL-6 levels in the vitreous 
      were significantly decreased in the treatment groups (P < 0.01), while NO levels 
      were significantly elevated (P < 0.01). At the same time, histopathologic 
      evaluation showed different retinal neuroepithelium structures in the different 
      groups. Immunoreactivity of VEGF was greater in the control group than in the 
      treatment groups. CONCLUSION: FXST was helpful in reconstructing retinal vessels 
      in the RVO model, protecting retinal structures and improving visual function, 
      and could inhibit the neovascular factor.
FAU - Zhou, Dan
AU  - Zhou D
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing 100730, China.
FAU - Wei, Wen-Bin
AU  - Wei WB
FAU - Yang, Cheng-Xun
AU  - Yang CX
FAU - Ding, Ning
AU  - Ding N
FAU - Liu, Yan
AU  - Liu Y
FAU - He, Man-Lin
AU  - He ML
FAU - Hou, Zhi-Jia
AU  - Hou ZJ
FAU - Zhou, Jin-Qiong
AU  - Zhou JQ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Interleukin-6)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Animals
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Interleukin-6/metabolism
MH  - Nitric Oxide/metabolism
MH  - Rabbits
MH  - Retinal Vein Occlusion/*drug therapy/metabolism
MH  - Vascular Endothelial Growth Factor A/metabolism
EDAT- 2010/12/18 06:00
MHDA- 2011/04/09 06:00
CRDT- 2010/12/18 06:00
PHST- 2010/12/18 06:00 [entrez]
PHST- 2010/12/18 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2010 Nov;123(22):3293-8.