PMID- 21167256
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20211020
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 489
IP  - 3
DP  - 2011 Feb 11
TI  - Local pretreatment with the cannabinoid CB1 receptor antagonist AM251 attenuates 
      methamphetamine intra-accumbens self-administration.
PG  - 187-91
LID - 10.1016/j.neulet.2010.12.013 [doi]
AB  - The endocannabinoid system is a potential target for therapeutic intervention of 
      substance abuse. Cannabinoid CB1 receptor antagonist decreases intravenous 
      methamphetamine self-administration in animal models. This study examined whether 
      the nucleus accumbens (NAcc) is a site of interaction between methamphetamine and 
      the CB1 receptor antagonist AM251. Male Sprague-Dawley rats were trained to lever 
      press and then were surgically implanted with a guide cannula into the right 
      NAcc. Rats were allowed one week to recover and then AM251 (0.1 or 1.0 mug/muL) was 
      reverse dialyzed directly into the NAcc prior to methamphetamine (10 mug/muL) 
      intra-accumbens self-administration. AM251 (1.0 mug/muL) reduced methamphetamine 
      self-administration while AM251 (0.1 mug/muL) had an intermediary effect. The 
      mechanism of self-administration attenuation is not known but could be mediated 
      by AM251 affecting the negative feedback from the NAcc to the ventral tegmental 
      area (VTA). This study provides evidence that the endocannabinoid system is 
      involved with rewarding effects of methamphetamine and suggests a possible 
      therapeutic intervention for methamphetamine abuse.
CI  - (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Rodriguez, Jesse S
AU  - Rodriguez JS
AD  - Cajal Neuroscience Institute, University of Texas at San Antonio, San Antonio, TX 
      78249, USA. rodriguezj13@uthscsa.edu
FAU - Boctor, Sherin Y
AU  - Boctor SY
FAU - Flores, Luke C
AU  - Flores LC
FAU - Phelix, Clyde F
AU  - Phelix CF
FAU - Martinez, Joe L Jr
AU  - Martinez JL Jr
LA  - eng
GR  - RR 013646-06A1/RR/NCRR NIH HHS/United States
GR  - G12 RR013646/RR/NCRR NIH HHS/United States
GR  - R01 DA004195-18/DA/NIDA NIH HHS/United States
GR  - DA 04195/DA/NIDA NIH HHS/United States
GR  - R01 DA004195/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101215
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Piperidines)
RN  - 0 (Pyrazoles)
RN  - 0 (Receptor, Cannabinoid, CB1)
RN  - 3I4FA44MAI (AM 251)
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Animals
MH  - Central Nervous System Stimulants/administration & dosage/*antagonists & 
      inhibitors
MH  - Conditioning, Operant/drug effects
MH  - Drug Interactions
MH  - Male
MH  - Methamphetamine/administration & dosage/*antagonists & inhibitors
MH  - Microdialysis/methods
MH  - Nucleus Accumbens/*drug effects
MH  - Piperidines/administration & dosage/*pharmacology
MH  - Pyrazoles/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Cannabinoid, CB1/*antagonists & inhibitors
MH  - Self Administration
PMC - PMC3031958
MID - NIHMS259484
EDAT- 2010/12/21 06:00
MHDA- 2011/04/30 06:00
PMCR- 2012/02/11
CRDT- 2010/12/21 06:00
PHST- 2010/09/10 00:00 [received]
PHST- 2010/11/30 00:00 [revised]
PHST- 2010/12/07 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
PHST- 2012/02/11 00:00 [pmc-release]
AID - S0304-3940(10)01547-8 [pii]
AID - 10.1016/j.neulet.2010.12.013 [doi]
PST - ppublish
SO  - Neurosci Lett. 2011 Feb 11;489(3):187-91. doi: 10.1016/j.neulet.2010.12.013. Epub 
      2010 Dec 15.