PMID- 21167408
OWN - NLM
STAT- MEDLINE
DCOM- 20110124
LR  - 20101220
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 64
IP  - 1
DP  - 2011 Jan
TI  - Abnormal inner root sheath of the hair follicle in the loose anagen hair 
      syndrome: an ultrastructural study.
PG  - 129-34
LID - 10.1016/j.jaad.2010.01.026 [doi]
AB  - BACKGROUND: Loose anagen hair syndrome (LAHS) is a disorder in which the hair 
      pulls out easily and painlessly from the scalp. It first manifests in early 
      childhood when the main concern of parents is that the sparse hair does not grow. 
      The hair density and length improve with age, but the looseness persists into 
      adulthood. OBJECTIVE: Light and electron microscopic studies of hair follicles 
      were performed to better define the microscopic changes seen in LAHS. METHODS: 
      Biopsy specimens were obtained from 4 patients, 3 children and 1 adult. The hair 
      follicles were studied by light and electron microscopy. RESULTS: The most 
      conspicuous structural changes were found in the inner root sheath complex of the 
      anagen follicle. With light microscopy, the keratinized Henle cell layer showed a 
      tortuous and irregular swelling. Irregular keratinization of the cuticle cells of 
      the inner root sheath and a swollen appearance of Huxley cells were also found. 
      With electron microscopy, the major pathological changes consisted of 
      intercellular edema in the prekeratinized Huxley cell zone and dyskeratosis of 
      Henle cells and cuticle cells of the inner root sheath. LIMITATIONS: The studies 
      were done on a small number of patients. CONCLUSIONS: Structural abnormalities of 
      the inner root sheath appear to disturb its normal supportive and anchoring 
      function and result in a loose attachment of the hair shaft to the anagen 
      follicle.
CI  - Copyright (c) 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. 
      All rights reserved.
FAU - Mirmirani, Paradi
AU  - Mirmirani P
AD  - Department of Dermatology, The Permanente Medical Group, Vallejo, California, 
      USA. Paradi.Mirmirani@kp.org
FAU - Uno, Hideo
AU  - Uno H
FAU - Price, Vera H
AU  - Price VH
LA  - eng
GR  - RR00167/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Biopsy, Needle
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hair Follicle/*abnormalities/*ultrastructure
MH  - Humans
MH  - Immunohistochemistry
MH  - Loose Anagen Hair Syndrome/diagnosis/*pathology
MH  - Male
MH  - Microscopy, Electron
MH  - Prognosis
MH  - Risk Assessment
MH  - Sampling Studies
EDAT- 2010/12/21 06:00
MHDA- 2011/01/25 06:00
CRDT- 2010/12/21 06:00
PHST- 2009/09/28 00:00 [received]
PHST- 2010/01/18 00:00 [revised]
PHST- 2010/01/20 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/01/25 06:00 [medline]
AID - S0190-9622(10)00106-4 [pii]
AID - 10.1016/j.jaad.2010.01.026 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2011 Jan;64(1):129-34. doi: 10.1016/j.jaad.2010.01.026.