PMID- 21167651
OWN - NLM
STAT- MEDLINE
DCOM- 20110907
LR  - 20181201
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 80
IP  - 5
DP  - 2011 Aug 1
TI  - Helical tomotherapy vs. intensity-modulated proton therapy for whole pelvis 
      irradiation in high-risk prostate cancer patients: dosimetric, normal tissue 
      complication probability, and generalized equivalent uniform dose analysis.
PG  - 1589-600
LID - 10.1016/j.ijrobp.2010.10.005 [doi]
AB  - PURPOSE: To compare intensity-modulated proton therapy (IMPT) and helical 
      tomotherapy (HT) treatment plans for high-risk prostate cancer (HRPCa) patients. 
      METHODS AND MATERIALS: The plans of 8 patients with HRPCa treated with HT were 
      compared with IMPT plans with two quasilateral fields set up (-100 degrees ; 100 degrees ) and 
      optimized with the Hyperion treatment planning system. Both techniques were 
      optimized to simultaneously deliver 74.2 Gy/Gy relative biologic effectiveness 
      (RBE) in 28 fractions on planning target volumes (PTVs)3-4 (P + proximal seminal 
      vesicles), 65.5 Gy/Gy(RBE) on PTV2 (distal seminal vesicles and rectum/prostate 
      overlapping), and 51.8 Gy/Gy(RBE) to PTV1 (pelvic lymph nodes). Normal tissue 
      calculation probability (NTCP) calculations were performed for the rectum, and 
      generalized equivalent uniform dose (gEUD) was estimated for the bowel cavity, 
      penile bulb and bladder. RESULTS: A slightly better PTV coverage and homogeneity 
      of target dose distribution with IMPT was found: the percentage of PTV volume 
      receiving >/= 95% of the prescribed dose (V(95%)) was on average > 97% in HT and > 
      99% in IMPT. The conformity indexes were significantly lower for protons than for 
      photons, and there was a statistically significant reduction of the IMPT 
      dosimetric parameters, up to 50 Gy/Gy(RBE) for the rectum and bowel and 60 
      Gy/Gy(RBE) for the bladder. The NTCP values for the rectum were higher in HT for 
      all the sets of parameters, but the gain was small and in only a few cases 
      statistically significant. CONCLUSIONS: Comparable PTV coverage was observed. 
      Based on NTCP calculation, IMPT is expected to allow a small reduction in rectal 
      toxicity, and a significant dosimetric gain with IMPT, both in medium-dose and in 
      low-dose range in all OARs, was observed.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Widesott, Lamberto
AU  - Widesott L
AD  - Agenzia Provinciale per Protonterapia, Trento, Italy. widesott@yahoo.it
FAU - Pierelli, Alessio
AU  - Pierelli A
FAU - Fiorino, Claudio
AU  - Fiorino C
FAU - Lomax, Antony J
AU  - Lomax AJ
FAU - Amichetti, Maurizio
AU  - Amichetti M
FAU - Cozzarini, Cesare
AU  - Cozzarini C
FAU - Soukup, Martin
AU  - Soukup M
FAU - Schneider, Ralf
AU  - Schneider R
FAU - Hug, Eugen
AU  - Hug E
FAU - Di Muzio, Nadia
AU  - Di Muzio N
FAU - Calandrino, Riccardo
AU  - Calandrino R
FAU - Schwarz, Marco
AU  - Schwarz M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20101216
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
RN  - 0 (Protons)
SB  - IM
MH  - Dose Fractionation, Radiation
MH  - Humans
MH  - Lymph Nodes/diagnostic imaging
MH  - Lymphatic Irradiation
MH  - Male
MH  - Organs at Risk/diagnostic imaging/radiation effects
MH  - Pelvis
MH  - Penis/diagnostic imaging/radiation effects
MH  - Photons/therapeutic use
MH  - Prostate/diagnostic imaging/radiation effects
MH  - Prostatic Neoplasms/diagnostic imaging/pathology/*radiotherapy
MH  - Proton Therapy
MH  - Radiation Injuries/prevention & control
MH  - Radiography
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Intensity-Modulated/*methods
MH  - Rectum/diagnostic imaging/radiation effects
MH  - Relative Biological Effectiveness
MH  - Seminal Vesicles/radiation effects
EDAT- 2010/12/21 06:00
MHDA- 2011/09/08 06:00
CRDT- 2010/12/21 06:00
PHST- 2009/10/01 00:00 [received]
PHST- 2010/07/16 00:00 [revised]
PHST- 2010/10/15 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/09/08 06:00 [medline]
AID - S0360-3016(10)03422-X [pii]
AID - 10.1016/j.ijrobp.2010.10.005 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2011 Aug 1;80(5):1589-600. doi: 
      10.1016/j.ijrobp.2010.10.005. Epub 2010 Dec 16.