PMID- 21167752
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20211020
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 33
IP  - 6
DP  - 2010 Dec 14
TI  - Dendritic cells in lupus are not required for activation of T and B cells but 
      promote their expansion, resulting in tissue damage.
PG  - 967-78
LID - 10.1016/j.immuni.2010.11.025 [doi]
AB  - Dendritic cells (DCs) initiate and control the adaptive immune response against 
      infections. However, their contributions to the anti-self adaptive immune 
      response in autoimmune disorders like systemic lupus erythematosus are uncertain. 
      By constitutively deleting DCs in MRL.Fas(lpr) mice, we show that they have 
      complex roles in murine lupus. The net effect of DC deletion was to ameliorate 
      disease. DCs were crucial for the expansion and differentiation of T cells but, 
      surprisingly, not required for their initial activation. Correspondingly, kidney 
      interstitial infiltrates developed in the absence of DCs, but failed to progress. 
      DC deletion concomitantly decreased inflammatory and regulatory T cell numbers. 
      Unexpectedly, plasmablast numbers and autoantibody concentrations depended on 
      DCs, in contrast to total serum immunoglobulin concentrations, suggesting an 
      effect of DCs on extrafollicular humoral responses. These findings reveal that 
      DCs operate in unanticipated ways in murine lupus and validate them as a 
      potential therapeutic target in autoimmunity.
FAU - Teichmann, Lino L
AU  - Teichmann LL
AD  - Department of Laboratory Medicine, Yale University School of Medicine, New Haven, 
      CT 06519, USA.
FAU - Ols, Michelle L
AU  - Ols ML
FAU - Kashgarian, Michael
AU  - Kashgarian M
FAU - Reizis, Boris
AU  - Reizis B
FAU - Kaplan, Daniel H
AU  - Kaplan DH
FAU - Shlomchik, Mark J
AU  - Shlomchik MJ
LA  - eng
GR  - R01 AR044077/AR/NIAMS NIH HHS/United States
GR  - R01-AR044077/AR/NIAMS NIH HHS/United States
GR  - R01 AR044077-12/AR/NIAMS NIH HHS/United States
GR  - R01 AR044077-11/AR/NIAMS NIH HHS/United States
GR  - R01 AR056632-02/AR/NIAMS NIH HHS/United States
GR  - R01 AR044077-13/AR/NIAMS NIH HHS/United States
GR  - R01 AR044077-10/AR/NIAMS NIH HHS/United States
GR  - R01 AR056632/AR/NIAMS NIH HHS/United States
GR  - R01 AR044077-14/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Autoantibodies)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
CIN - Immunity. 2010 Dec 14;33(6):840-2. PMID: 21168776
MH  - Animals
MH  - Autoantibodies/biosynthesis/genetics
MH  - B-Lymphocytes/immunology/*metabolism/pathology
MH  - Blood Component Removal
MH  - Cell Differentiation
MH  - Cell Movement
MH  - Dendritic Cells/immunology/*metabolism/pathology
MH  - Disease Models, Animal
MH  - Humans
MH  - Immunoglobulin Class Switching
MH  - Interferon-gamma/metabolism
MH  - Lupus Erythematosus, Systemic/*immunology
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred MRL lpr
MH  - T-Lymphocyte Subsets/immunology/*metabolism/pathology
MH  - T-Lymphocytes, Regulatory/immunology/*metabolism/pathology
PMC - PMC3010763
MID - NIHMS256686
EDAT- 2010/12/21 06:00
MHDA- 2011/05/10 06:00
PMCR- 2011/12/14
CRDT- 2010/12/21 06:00
PHST- 2010/07/09 00:00 [received]
PHST- 2010/09/09 00:00 [revised]
PHST- 2010/10/07 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
PHST- 2011/12/14 00:00 [pmc-release]
AID - S1074-7613(10)00455-3 [pii]
AID - 10.1016/j.immuni.2010.11.025 [doi]
PST - ppublish
SO  - Immunity. 2010 Dec 14;33(6):967-78. doi: 10.1016/j.immuni.2010.11.025.