PMID- 21167753
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20191210
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Linking)
VI  - 33
IP  - 6
DP  - 2010 Dec 14
TI  - Transcription factor miz-1 is required to regulate interleukin-7 receptor 
      signaling at early commitment stages of B cell differentiation.
PG  - 917-28
LID - 10.1016/j.immuni.2010.11.028 [doi]
AB  - B cell development requires the coordinated action of transcription factors and 
      cytokines, in particular interleukin-7 (IL-7). We report that mice lacking the 
      POZ (Poxvirus and zinc finger) domain of the transcription factor Miz-1 
      (Zbtb17(DeltaPOZ/DeltaPOZ)) almost entirely lacked follicular B cells, as shown by the 
      fact that their progenitors failed to activate the Jak-Stat5 pathway and to 
      upregulate the antiapoptotic gene Bcl2 upon IL-7 stimulation. We show that Miz-1 
      exerted a dual role in the interleukin-7 receptor (IL-7R) pathway by directly 
      repressing the Janus kinase (Jak) inhibitor suppressor of cytokine signaling 1 
      (Socs1) and by activating Bcl2 expression. Zbtb17(DeltaPOZ/DeltaPOZ) (Miz-1-deficient) B 
      cell progenitors had low expression of early B cell genes as transcription factor 
      3 (Tcf3) and early B cell factor 1 (Ebf1) and showed a propensity for apoptosis. 
      Only the combined re-expression of Bcl2 and Ebf1 could reconstitute the ability 
      of Miz-1-deficient precursors to develop into CD19(+) B cells.
FAU - Kosan, Christian
AU  - Kosan C
AD  - Institut de recherches cliniques de Montreal (IRCM), Montreal, Quebec H2W 1R7, 
      Canada.
FAU - Saba, Ingrid
AU  - Saba I
FAU - Godmann, Maren
AU  - Godmann M
FAU - Herold, Stefanie
AU  - Herold S
FAU - Herkert, Barbara
AU  - Herkert B
FAU - Eilers, Martin
AU  - Eilers M
FAU - Moroy, Tarik
AU  - Moroy T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Nuclear Proteins)
RN  - 0 (Protein Inhibitors of Activated STAT)
RN  - 0 (Receptors, Interleukin-7)
RN  - 0 (bcl-Associated Death Protein)
RN  - EC 2.3.2.27 (Miz1 protein, mouse)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/immunology/*metabolism/pathology
MH  - Bone Marrow/*pathology
MH  - Cell Differentiation/genetics/immunology
MH  - Cell Lineage/genetics/immunology
MH  - Cell Survival/genetics
MH  - Cells, Cultured
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Mutation/genetics
MH  - Nuclear Proteins/genetics/immunology/*metabolism
MH  - Protein Inhibitors of Activated STAT/genetics/immunology/*metabolism
MH  - Receptors, Interleukin-7/genetics/immunology/*metabolism
MH  - Signal Transduction/genetics/immunology
MH  - Ubiquitin-Protein Ligases
MH  - bcl-Associated Death Protein/*biosynthesis/genetics/immunology
EDAT- 2010/12/21 06:00
MHDA- 2011/05/10 06:00
CRDT- 2010/12/21 06:00
PHST- 2009/11/11 00:00 [received]
PHST- 2010/08/10 00:00 [revised]
PHST- 2010/10/01 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
AID - S1074-7613(10)00458-9 [pii]
AID - 10.1016/j.immuni.2010.11.028 [doi]
PST - ppublish
SO  - Immunity. 2010 Dec 14;33(6):917-28. doi: 10.1016/j.immuni.2010.11.028.