PMID- 21167768
OWN - NLM
STAT- MEDLINE
DCOM- 20110510
LR  - 20220317
IS  - 1879-0593 (Electronic)
IS  - 1368-8375 (Linking)
VI  - 47
IP  - 2
DP  - 2011 Feb
TI  - Hypoxia-inducible factor-1 alpha, in association with TWIST2 and SNIP1, is a 
      critical prognostic factor in patients with tongue squamous cell carcinoma.
PG  - 92-7
LID - 10.1016/j.oraloncology.2010.11.014 [doi]
AB  - It has become apparent that hypoxia and hypoxia-inducible factor-1 (HIF-1) 
      activation have the potential of modulating the activity of major 
      epithelial-mesenchymal transition (EMT)-triggering pathways by regulating the 
      expression and activity levels of major transcriptional repressors. The aim of 
      our study was to elucidate the role of HIF-1alpha and HIF-2alpha, and EMT regulators 
      TWIST2 and SMAD nuclear interacting protein-1 (SNIP1) in tongue squamous cell 
      carcinoma (TSCC). A retrospective analysis of 89 patients with TSCC from 
      Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, 
      Sichuan University between 2002 and 2005 was performed using immunohistochemistry 
      in paraffin-embedded and formalin-fixed tissues to analyze HIF-1alpha, HIF-2alpha, TWIST2 
      and SNIP1 expression. The association between HIF-1alpha, HIF-2alpha, TWIST2 and SNIP1 
      expression and patient survivals was investigated. Our results showed that 
      overexpression of HIF-1alpha, HIF-2alpha, TWIST2 and SNIP1 were shown in 49.44% (44/89), 
      55.06% (49/89), 44.94% (40/89) and 34.83% (31/89) of TSCC, respectively. 
      Overexpression of HIF-1alpha, TWIST2 and SNIP1 in TSCC was associated with a shorter 
      disease-free survival (P=0.003, P=0.001, P=0.040, respectively), and HIF-2alpha had 
      no significant association with either overall survival (P=0.195) or disease-free 
      survival (P=0.356). Co-expression of more than two markers of HIF-1alpha, TWIST2 and 
      SNIP1 was an independent prognostic indicator for both overall survival and 
      disease-free survival by multivariate Cox proportional hazards model. It is 
      proposed that co-expression of more than two markers from HIF-1alpha, TWIST2 and 
      SNIP1 might be a significant prognostic predictor in patients with TSCC.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Liang, Xinhua
AU  - Liang X
AD  - Department of Oral and Maxillofacial Surgery, West China College of Stomatology, 
      Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, 
      People's Republic of China.
FAU - Zheng, Min
AU  - Zheng M
FAU - Jiang, Jian
AU  - Jiang J
FAU - Zhu, Guiquan
AU  - Zhu G
FAU - Yang, Jing
AU  - Yang J
FAU - Tang, Yaling
AU  - Tang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101216
PL  - England
TA  - Oral Oncol
JT  - Oral oncology
JID - 9709118
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (SNIP1 protein, human)
RN  - 0 (TWIST2 protein, human)
RN  - 0 (Twist-Related Protein 1)
RN  - 1B37H0967P (endothelial PAS domain-containing protein 1)
SB  - IM
MH  - Adult
MH  - Basic Helix-Loop-Helix Transcription Factors/genetics/*metabolism
MH  - Carcinoma, Squamous Cell/genetics/*metabolism/mortality
MH  - Disease-Free Survival
MH  - Epithelial-Mesenchymal Transition/physiology
MH  - Female
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/genetics/*metabolism
MH  - Intracellular Signaling Peptides and Proteins/genetics/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/genetics/*metabolism
MH  - Prognosis
MH  - RNA-Binding Proteins
MH  - Repressor Proteins/genetics/*metabolism
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Tongue Neoplasms/genetics/*metabolism/mortality
MH  - Twist-Related Protein 1/genetics/*metabolism
EDAT- 2010/12/21 06:00
MHDA- 2011/05/11 06:00
CRDT- 2010/12/21 06:00
PHST- 2010/10/28 00:00 [received]
PHST- 2010/11/22 00:00 [revised]
PHST- 2010/11/22 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/05/11 06:00 [medline]
AID - S1368-8375(10)00365-9 [pii]
AID - 10.1016/j.oraloncology.2010.11.014 [doi]
PST - ppublish
SO  - Oral Oncol. 2011 Feb;47(2):92-7. doi: 10.1016/j.oraloncology.2010.11.014. Epub 
      2010 Dec 16.