PMID- 21167967
OWN - NLM
STAT- MEDLINE
DCOM- 20110331
LR  - 20101220
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 683
IP  - 2
DP  - 2011 Jan 10
TI  - Analysis of time-dependent conjugation of gold nanoparticles with an 
      antiparkinsonian molecule by using curve resolution methods.
PG  - 170-7
LID - 10.1016/j.aca.2010.10.014 [doi]
AB  - In this work, the time-dependent conjugation process between a thiolated molecule 
      (with anti-parkinsonian properties) and gold nanoparticles has been monitored and 
      studied by the combined use of fast acquisition Ultra Violet-Visible (UV-Vis) 
      spectra and the ability of Multivariate Curve Resolution-Alternating Least 
      Squares (MCR-ALS) technique. From the highly informative kinetic profiles 
      obtained it was possible to extract quantitative and qualitative information of 
      the conjugation process which includes i) time-dependent concentration profiles 
      and pure spectra of species involved on conjugation process, ii) estimation of 
      molecule concentration necessary for the completeness of the conjugation 
      reaction, iii) molecule footprint and iv) free energy of molecule adsorption.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Amigo, Jose Manuel
AU  - Amigo JM
AD  - Department of Food Science, Quality & Technology, Faculty of Life Sciences, 
      University of Copenhagen, Rolighedsvej 30, DK-1958 Copenhagen, Frederiksberg C, 
      Denmark. jmar@life.ku.dk
FAU - Bastus, Neus G
AU  - Bastus NG
FAU - Hoen, Rob
AU  - Hoen R
FAU - Vazquez-Campos, Socorro
AU  - Vazquez-Campos S
FAU - Varon, Miriam
AU  - Varon M
FAU - Royo, Miriam
AU  - Royo M
FAU - Puntes, Victor
AU  - Puntes V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101030
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (Antiparkinson Agents)
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - Antiparkinson Agents/*chemistry
MH  - Gold/*chemistry
MH  - Kinetics
MH  - Least-Squares Analysis
MH  - Metal Nanoparticles/*chemistry
MH  - Spectrophotometry, Ultraviolet/*methods
MH  - Thermodynamics
MH  - Time Factors
EDAT- 2010/12/21 06:00
MHDA- 2011/04/01 06:00
CRDT- 2010/12/21 06:00
PHST- 2010/07/27 00:00 [received]
PHST- 2010/10/11 00:00 [revised]
PHST- 2010/10/12 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
AID - S0003-2670(10)01298-5 [pii]
AID - 10.1016/j.aca.2010.10.014 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2011 Jan 10;683(2):170-7. doi: 10.1016/j.aca.2010.10.014. Epub 
      2010 Oct 30.