PMID- 21168001
OWN - NLM
STAT- MEDLINE
DCOM- 20110412
LR  - 20220309
IS  - 1532-8430 (Electronic)
IS  - 0022-0736 (Linking)
VI  - 44
IP  - 1
DP  - 2011 Jan-Feb
TI  - Grade 3 ischemia on the admission electrocardiogram is associated with severe 
      microvascular injury on cardiac magnetic resonance imaging after ST elevation 
      myocardial infarction.
PG  - 49-57
LID - 10.1016/j.jelectrocard.2010.09.013 [doi]
AB  - BACKGROUND: Grade 3 ischemia during ST elevation myocardial infarction (STEMI) is 
      defined as ST elevation with distortion of the terminal portion of the QRS on 
      electrocardiogram (ECG). The aim of this study was to evaluate the effect of 
      ischemic grade on cardiac magnetic resonance (CMR) imaging infarct 
      characteristics such as infarct size, microvascular obstruction (MVO), 
      intramyocardial hemorrhage (IMH), and myocardial salvage. METHODS: Patients with 
      STEMI treated with primary percutaneous coronary intervention had a 12-lead ECG 
      on presentation for analysis of ischemic grade. Gadolinium-enhanced CMR imaging 
      was performed within 7 days to assess infarct size, MVO, IMH, and myocardial 
      salvage. RESULTS: Of the 37 patients enrolled in the study, grade 3 ischemia was 
      present in 32%. Those with grade 3 ischemia had higher peak troponin I levels (P 
      = .013), more MVO (P < .001), more IMH (P < .001), larger infarct size (P = 
      .025), and less myocardial salvage (P = .012). Regression analysis found that 
      grade 3 ischemia, infarct size, and peak troponin I level were significantly 
      associated with MVO and IMH. CONCLUSION: Grade 3 ischemia on the admission ECG 
      during STEMI is closely associated with the development of severe microvascular 
      damage on CMR imaging.
CI  - Crown Copyright (c) 2011. Published by Elsevier Inc. All rights reserved.
FAU - Weaver, James C
AU  - Weaver JC
AD  - Department of Cardiology, St George Hospital, Sydney, Australia. 
      james.weaver@sesiahs.health.nsw.gov.au
FAU - Rees, David
AU  - Rees D
FAU - Prasan, Ananth M
AU  - Prasan AM
FAU - Ramsay, David D
AU  - Ramsay DD
FAU - Binnekamp, Maurits F
AU  - Binnekamp MF
FAU - McCrohon, Jane A
AU  - McCrohon JA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Electrocardiol
JT  - Journal of electrocardiology
JID - 0153605
SB  - IM
MH  - Aged
MH  - Electrocardiography/*methods
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Microcirculation
MH  - Microvessels/*pathology
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis/*pathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Statistics as Topic
EDAT- 2010/12/21 06:00
MHDA- 2011/04/13 06:00
CRDT- 2010/12/21 06:00
PHST- 2010/04/30 00:00 [received]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - S0022-0736(10)00394-8 [pii]
AID - 10.1016/j.jelectrocard.2010.09.013 [doi]
PST - ppublish
SO  - J Electrocardiol. 2011 Jan-Feb;44(1):49-57. doi: 
      10.1016/j.jelectrocard.2010.09.013.