PMID- 21168783
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20191210
IS  - 1545-1534 (Electronic)
IS  - 1080-6032 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Dec
TI  - Postexercise peripheral oxygen saturation after completion of the 6-minute walk 
      test predicts successfully reaching the summit of Aconcagua.
PG  - 309-17
LID - 10.1016/j.wem.2010.09.003 [doi]
AB  - OBJECTIVE: The 6-minute walk test (6MWT) is a single measurement of functional 
      status in patients with cardiovascular disease. It has not been studied at high 
      altitude. We investigate the screening value of 6-minute walk distance (6MWD) and 
      postexercise vital sign (VS) measurements as predictors of successfully reaching 
      the summit or development of acute mountain sickness (AMS) on Aconcagua (6962 m). 
      METHODS: Prospective observational cohort in Aconcagua Provincial Park, 
      Argentina. Adults climbing the normal route who registered with base camp 
      physicians were included. There were no exclusion criteria. VSs were measured 
      before (resting) and after (postexercise) completion of 6MWT while volunteers 
      acclimatized at Plaza de Mulas base camp (4365 m). Volunteers proceeded towards 
      the summit at their own pace and upon descent returned a questionnaire with 
      maximum altitude reached and Lake Louise AMS Self-report Score (LLSelf). RESULTS: 
      One hundred twenty-four volunteers completed the 6MWT. Sixty-four volunteers 
      (51.6%) completed questionnaires; 56% summited. Median LLSelf was 4 (IQR: 
      3.0-6.5). There was no association between any resting or postexercise VS 
      measurements and AMS. However, mean postexercise SpO(2) was 80.8% in summiters 
      and 76.4% in nonsummiters, a difference of -4.4% (95% CI: -6.7 to -2.0, p = 
      0.0005). Postexercise SpO(2) < 75% had 97.2% sensitivity and negative likelihood 
      ratio of 0.086 in predicting the outcome of successfully reaching the summit: 
      only one climber with SpO(2) < 75% successfully reached the summit. CONCLUSIONS: 
      This study provides the first published data on 6MWD recorded in the field at 
      high altitude. Postexercise SpO(2) < 75% may be a useful screening test for 
      predicting the outcome of successfully reaching the summit of Aconcagua.
CI  - Copyright (c) 2010 Wilderness Medical Society. Published by Elsevier Inc. All 
      rights reserved.
FAU - Lazio, Matthew P
AU  - Lazio MP
AD  - Department of Emergency Medicine, Feinberg School of Medicine, Northwestern 
      University, Chicago, IL, USA. matt.lazio@gmail.com
FAU - Van Roo, Jon D
AU  - Van Roo JD
FAU - Pesce, Carlos
AU  - Pesce C
FAU - Malik, Sanjeev
AU  - Malik S
FAU - Courtney, D Mark
AU  - Courtney DM
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20100921
PL  - United States
TA  - Wilderness Environ Med
JT  - Wilderness & environmental medicine
JID - 9505185
RN  - S88TT14065 (Oxygen)
SB  - IM
CIN - Wilderness Environ Med. 2011 Jun;22(2):194; author reply 194-5. PMID: 21440469
MH  - *Acclimatization
MH  - Adult
MH  - Altitude
MH  - Altitude Sickness/prevention & control
MH  - Argentina
MH  - Blood Pressure
MH  - Exercise Test/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - *Mountaineering
MH  - Oxygen/*metabolism
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Surveys and Questionnaires
MH  - Vital Signs
MH  - *Walking
EDAT- 2010/12/21 06:00
MHDA- 2011/03/02 06:00
CRDT- 2010/12/21 06:00
PHST- 2010/05/20 00:00 [received]
PHST- 2010/09/02 00:00 [revised]
PHST- 2010/09/02 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - S1080-6032(10)00295-4 [pii]
AID - 10.1016/j.wem.2010.09.003 [doi]
PST - ppublish
SO  - Wilderness Environ Med. 2010 Dec;21(4):309-17. doi: 10.1016/j.wem.2010.09.003. 
      Epub 2010 Sep 21.