PMID- 21170251
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20231103
IS  - 0976-5131 (Electronic)
IS  - 0971-6580 (Print)
IS  - 0971-6580 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Jul
TI  - Haematolohical profile of subacute oral toxicity of molybdenum and ameliorative 
      efficacy of copper salt in goats.
PG  - 82-5
LID - 10.4103/0971-6580.72676 [doi]
AB  - Molybdenum toxicity produces a state of secondary hypocuprosis, resulting into 
      alterations in normal hematological profile. In the present study, ammonium 
      molybdate alone and with copper sulfate (II) pentahydrate (ameliorative agent) 
      was administered orally for 30 consecutive days in healthy goats of group 1 and 
      2, respectively, to access the effect on the hematological profile on different 
      predetermined days of dosing. Administration of ammonium molybdate alone produced 
      significant decline in the mean values of hemoglobin (Hb), packed cell volume 
      (PCV), total leukocyte count (TLC), total erythrocyte count (TEC), and mean 
      corpuscular hemoglobin concentration (MCHC), with a significant increase in 
      neutrophil level and mean corpuscular volume (MCV). However, values of 
      erythrocyte sedimentation rate, mean corpuscular hemoglobin, and differential 
      leukocyte count were not significantly altered. On comparing observations of 
      ameliorative group with the group 1 goats, it is concluded that the ameliorative 
      copper salt has beneficial effects in alleviating the alterations in the values 
      of Hb, PCV, TLC, TEC, MCV, MCHC, and neutrophils.
FAU - Kusum
AU  - Kusum
AD  - Divisions of Pharmacology and Toxicology, Faculty of Veterinary Sciences and 
      Animal Husbandry, SKUAST, R.S. Pura, Jammu, Jammu and Kashmir, India.
FAU - Raina, R
AU  - Raina R
FAU - Verma, P K
AU  - Verma PK
FAU - Pankaj, N K
AU  - Pankaj NK
FAU - Kant, V
AU  - Kant V
FAU - Kumar, J
AU  - Kumar J
FAU - Srivastava, A K
AU  - Srivastava AK
LA  - eng
PT  - Journal Article
PL  - India
TA  - Toxicol Int
JT  - Toxicology international
JID - 101191279
PMC - PMC2997461
OTO - NOTNLM
OT  - Ammonium molybdate
OT  - copper sulfate
OT  - goats
OT  - hematological profile
COIS- Conflict of Interest: None declared
EDAT- 2010/12/21 06:00
MHDA- 2010/12/21 06:01
PMCR- 2010/07/01
CRDT- 2010/12/21 06:00
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2010/12/21 06:01 [medline]
PHST- 2010/07/01 00:00 [pmc-release]
AID - TI-17-82 [pii]
AID - 10.4103/0971-6580.72676 [doi]
PST - ppublish
SO  - Toxicol Int. 2010 Jul;17(2):82-5. doi: 10.4103/0971-6580.72676.