PMID- 21171377
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20171116
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 23
IP  - 1
DP  - 2007 Feb
TI  - [Effect of ligustrazine on expression of Fas/FasL in pulmonary injury induced by 
      ischemia/reperfusion in rabbits].
PG  - 87-91
AB  - AIM: To investigate the effect of ligustrazine (LGT) on expression of Fas/FasL 
      mRNA during pulmonary ischemia/reperfusion injury (PI/RI) in the rabbits. 
      METHODS: Single lung ischemia/reperfusion animal model was used in this study. 
      The rabbits were randomly divided into three groups (n = 30, in each): sham 
      operated group (Sham), I/R group (I/R) and I/R + LGT group (I/R + LGT). Changes 
      of several parameters which included apoptotic index (AI), wet to dry ratio of 
      lung tissue weight (W/D) and index of quantitative assessment of histologic lung 
      injury (IQA) were measured at 1h, 3h, 5h after reperfusion in lung tissue. 
      Meanwhile the location and expression of Fas/FasL mRNA were observed. Lung tissue 
      was prepared for light microscopic and electron microscopic ob servation at 1 h, 
      3 h, 5 h after reperfusion. RESULTS: As compared with group I/R, Fas/FasL mRNA 
      slightly expressed in intima and extima of small pulmonary artery, alveoli, and 
      bronchiole epithelia in group LGT. The values of AI, W/D and IQA showed 
      significantly lower in group I/R + LGT than that in group I/R at 1 h, 3 h, 5 h 
      after reperfusion in lung tissue (P < 0.01 and P < 0.05). Meanwhile, abnormal 
      changes of the lung tissue in morphologically were lessen markedly in group I/R + 
      LGT. CONCLUSION: Ligustrazine has notable protective effects on PI/RI in rabbits 
      by inhibiting Fas/FasL mRNA express in lung tissue and decreasing apoptosis.
FAU - Wang, Wan-Tie
AU  - Wang WT
AD  - Department of Pathophysiology, Wenzhou Medical College, Wenzhou 325027, China. 
      wzwwt@tom.com
FAU - Wang, Xiao-Yang
AU  - Wang XY
FAU - Chen, Rui-Jie
AU  - Chen RJ
FAU - Chen, Xi-Wen
AU  - Chen XW
FAU - Hao, Mao-Lin
AU  - Hao ML
FAU - Wang, Fang-Yan
AU  - Wang FY
FAU - Fang, Zhou-Xi
AU  - Fang ZX
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - 0 (Fas Ligand Protein)
RN  - 0 (Pyrazines)
RN  - 0 (RNA, Messenger)
RN  - 0 (fas Receptor)
RN  - V80F4IA5XG (tetramethylpyrazine)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Fas Ligand Protein/*metabolism
MH  - Lung/blood supply
MH  - Lung Injury/*metabolism/pathology
MH  - Pyrazines/*pharmacology
MH  - RNA, Messenger/genetics
MH  - Rabbits
MH  - Reperfusion Injury/*metabolism/pathology
MH  - fas Receptor/*metabolism
EDAT- 2007/02/01 00:00
MHDA- 2012/03/27 06:00
CRDT- 2010/12/22 06:00
PHST- 2010/12/22 06:00 [entrez]
PHST- 2007/02/01 00:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007 Feb;23(1):87-91.