PMID- 21175099
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20131121
IS  - 0334-018X (Print)
IS  - 0334-018X (Linking)
VI  - 23
IP  - 9
DP  - 2010 Sep
TI  - Investigation of acquired von Willebrand Syndrome in children with 
      hypothyroidism: reversal after treatment with thyroxine.
PG  - 967-74
AB  - BACKGROUND: Acquired von Willebrand Syndrome (AvWS) is a rare bleeding disorder 
      associated with various underlying conditions. Many case reports have been 
      published so far on bleeding tendency in hypothyroidism resembling AvWS. 
      OBJECTIVE: This study was designed to define the relationship between 
      hypothyroidism and AvWS and to investigate the effects of L-thyroxine treatment. 
      SUBJECTS: Twenty four hypothyroid patients were included in the study. Nineteen 
      patients were evaluated during treatment, 5 patients were evaluated before 
      hormone replacement. METHODS: Complete coagulation screening tests including 
      levels of von Willebrand Factor antigen (vWF:Ag) and functional activity 
      (vWF:RCo) were measured by thrombocyte aggregometer. RESULTS: We demonstrated low 
      vWF:Ag and vWF:RCo in 13 patients. Two of the 13 patients were diagnosed as AvWS, 
      while another 2 patients were diagnosed as hereditary vWD Type 1. The remaining 
      patients are still being followed-up. CONCLUSION: We would like to attract the 
      attention of paediatricians to the possibility of bleeding due to decreased 
      activity of vWF in hypothyroid children.
FAU - Olukman, Ozgur
AU  - Olukman O
AD  - Dr. Behcet Uz Children's Hospital, Izmir, Turkey. drolukman2002@yahoo.com
FAU - Sahin, Ulku
AU  - Sahin U
FAU - Kavakli, Tulay
AU  - Kavakli T
FAU - Kavakli, Kaan
AU  - Kavakli K
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Pediatr Endocrinol Metab
JT  - Journal of pediatric endocrinology & metabolism : JPEM
JID - 9508900
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Hypothyroidism/*blood/complications/drug therapy
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Thyroxine/*therapeutic use
MH  - von Willebrand Diseases/*etiology
EDAT- 2010/12/24 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
PST - ppublish
SO  - J Pediatr Endocrinol Metab. 2010 Sep;23(9):967-74.