PMID- 21175878
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20181201
IS  - 1574-695X (Electronic)
IS  - 0928-8244 (Linking)
VI  - 61
IP  - 2
DP  - 2011 Mar
TI  - Helicobacter pylori defines local immune response through interaction with 
      dendritic cells.
PG  - 168-78
LID - 10.1111/j.1574-695X.2010.00761.x [doi]
AB  - The bacterial pathogen Helicobacter pylori colonizes the human gastric and 
      duodenal mucosa, evades clearance by the host response and is associated with 
      peptic ulcer disease and an increased risk of gastric adenocarcinoma. Dendritic 
      cells (DCs) are initiators of the immune response to H. pylori. The aim of the 
      current study was to investigate the interaction between H. pylori with DCs. To 
      determine the impact of H. pylori on the maturation and the activation of 
      monocyte-derived DCs, the effect of 20 clinical H. pylori strains with different 
      inflammatory backgrounds on adenocarcinoma gastric epithelial cells was 
      investigated. The inflammatory background was defined according to the degree of 
      lymphocyte and granulocyte infiltration and the bacterial density at the site of 
      infection. DC maturation and activation varied after exposure to the different 
      strains. While maturation appeared to be independent of any virulence factor 
      tested, a significant increase in the average level of cytokine production was 
      observed for the proinflammatory cytokines interleukin-12 (IL-12), tumour 
      necrosis factor-alpha, IL-6 and IL-1beta when comparing strains with low inflammatory 
      backgrounds with those of the medium or high backgrounds. In conclusion, the DC 
      response towards different strains in vitro was associated with the clinical 
      outcome of the individual host, suggesting a major role of this cell type in 
      modulating strain-specific H. pylori infection.
CI  - (c) 2010 Federation of European Microbiological Societies. Published by Blackwell 
      Publishing Ltd. All rights reserved.
FAU - Andres, Sonke
AU  - Andres S
AD  - Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 
      Stockholm, Sweden.
FAU - Schmidt, Heather-Marie A
AU  - Schmidt HM
FAU - Mitchell, Hazel
AU  - Mitchell H
FAU - Rhen, Mikael
AU  - Rhen M
FAU - Maeurer, Markus
AU  - Maeurer M
FAU - Engstrand, Lars
AU  - Engstrand L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101222
PL  - England
TA  - FEMS Immunol Med Microbiol
JT  - FEMS immunology and medical microbiology
JID - 9315554
RN  - 0 (Cytokines)
SB  - IM
MH  - Aged
MH  - Cell Line
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*immunology
MH  - Gastric Mucosa/*immunology
MH  - Helicobacter Infections/*immunology/*microbiology/pathology
MH  - Helicobacter pylori/*immunology/isolation & purification
MH  - Humans
MH  - Middle Aged
EDAT- 2010/12/24 06:00
MHDA- 2011/05/24 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - 10.1111/j.1574-695X.2010.00761.x [doi]
PST - ppublish
SO  - FEMS Immunol Med Microbiol. 2011 Mar;61(2):168-78. doi: 
      10.1111/j.1574-695X.2010.00761.x. Epub 2010 Dec 22.