PMID- 21176382
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20161018
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 18
IP  - 6
DP  - 2010 Dec
TI  - [Probability of high resolution full match for human leukocyte antigen loci in 
      unrelated donors and recipients with low resolution match].
PG  - 1617-20
AB  - This study was aimed to analyze the possibility of high resolution matching for 
      human leukocyte antigen (HLA) loci in unrelated donor-recipient pair with low 
      resolution match in HLA-A, -B, -DRB1 loci. Samples were genotyped for HLA-A, -B, 
      -C, -DRB1 and -DQB1 by polymerase chain reaction sequence based typing (PCR-SBT). 
      The results showed that the total number of patients and the donors were 166 and 
      274. 97 (58.43%) patients were matched for 1 donor and 47 (28.31%) patients were 
      matched for 2 donors at low resolution level; among 274 donor-recipient pairs, 
      HLA-A, -B, -C, -DRB1 and -DQB1 loci matching for 6/10, 7/10, 8/10, 9/10 and 10/10 
      were 32 (11.68%), 54 (19.71%), 62 (22.63%), 49 (17.88%) and 48 (17.52%) 
      respectively; there were mismatch in HLA-A, -B, -C, -DRB1 and -DQB1 loci, and the 
      most mismatch was in HLA-C locus. The number of alleles of HLA-A, -B, -C, -DRB1 
      and -DQB1 loci were 23, 46, 21, 30 and 17 respectively in the donors. The alleles 
      number HLA-A, -B, -C, -DRB1 and -DQB1 loci were 20, 40, 22, 29 and 16 
      respectively in the patients; the haplotype number of HLA loci were 311 in the 
      donors and 224 in the patients. The high frequency of haplotype was 
      A*02:07-B*46:01-C*01:02-DRB1*09:01:02-DQB1*03:03 (5.63% and 6.88%). It is 
      concluded that the probability of high resolution mismatch of HLA loci is high in 
      unrelated donor-recipient pairs with low resolution match in HLA-A, -B, -DRB1 
      loci.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Institute of Transfusion Medicine, Blood Center of Zhejiang Province, Hangzhou 
      310006, Zhejiang Province, China.
FAU - Zhu, Fa-Ming
AU  - Zhu FM
FAU - He, Yan-Min
AU  - He YM
FAU - Tao, Su-Dan
AU  - Tao SD
FAU - Wang, Wei
AU  - Wang W
FAU - He, Jun-Jun
AU  - He JJ
FAU - Lu, Hang-Jun
AU  - Lu HJ
FAU - Yan, Li-Xing
AU  - Yan LX
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Gene Frequency
MH  - Genotype
MH  - HLA Antigens/genetics/*immunology
MH  - HLA-A Antigens/genetics/immunology
MH  - HLA-B Antigens/genetics/immunology
MH  - HLA-C Antigens/genetics/immunology
MH  - HLA-DQ Antigens/genetics/immunology
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics/immunology
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Hematopoietic Stem Cell Transplantation/methods
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Probability
MH  - Tissue Donors
EDAT- 2010/12/24 06:00
MHDA- 2011/10/07 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - 1009-2137(2010)06-1617-04 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Dec;18(6):1617-20.