PMID- 21177285
OWN - NLM
STAT- MEDLINE
DCOM- 20110610
LR  - 20220309
IS  - 1464-3553 (Electronic)
IS  - 0379-864X (Print)
IS  - 0379-864X (Linking)
VI  - 36
IP  - 3
DP  - 2011 Mar
TI  - Different profiles of main and accessory olfactory bulb mitral/tufted cell 
      projections revealed in mice using an anterograde tracer and a whole-mount, 
      flattened cortex preparation.
PG  - 251-60
LID - 10.1093/chemse/bjq120 [doi]
AB  - A whole-mount, flattened cortex preparation was developed to compare profiles of 
      axonal projections from main olfactory bulb (MOB) and accessory olfactory bulb 
      (AOB) mitral and tufted (M/T) cells. After injections of the anterograde tracer, 
      Phaseolus vulgaris leucoagglutinin, mapping of labeled axons using a Neurolucida 
      system showed that M/T cells in the AOB sent axons primarily to the medial and 
      posterior lateral cortical amygdala, with minimal branching into the piriform 
      cortex. By contrast, M/T cells in the MOB displayed a network of collaterals that 
      branched off the primary axon at several levels of the lateral olfactory tract 
      (LOT). Collaterals emerging from the LOT into the anterior piriform cortex were 
      often observed crossing into the posterior piriform cortex. M/T cells in the 
      dorsal MOB extended fewer collaterals from the primary axon in the rostral LOT 
      than did M/T cells from the anterior or ventral MOB. MOB M/T cells that projected 
      to the medial amygdala did not do so exclusively, also sending collaterals to the 
      anterior cortical amygdala as well as to olfactory cortical regions. This 
      arrangement may be related to the ability of social experience to modify the 
      response of mice to volatile pheromones detected by the main olfactory system.
FAU - Kang, Ningdong
AU  - Kang N
AD  - Department of Biology, Boston University, Boston, MA 02215, USA.
FAU - Baum, Michael J
AU  - Baum MJ
FAU - Cherry, James A
AU  - Cherry JA
LA  - eng
GR  - R01 DC 008962/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101221
PL  - England
TA  - Chem Senses
JT  - Chemical senses
JID - 8217190
RN  - 0 (Contrast Media)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Phytohemagglutinins)
RN  - 0 (leukoagglutinins, plants)
SB  - IM
MH  - Animals
MH  - Axons/chemistry/metabolism
MH  - Contrast Media/metabolism
MH  - Fluorescent Dyes/metabolism
MH  - Male
MH  - Mice
MH  - Olfactory Bulb/*anatomy & histology/chemistry/metabolism
MH  - Olfactory Pathways/anatomy & histology/chemistry
MH  - Phytohemagglutinins/metabolism
PMC - PMC3038272
EDAT- 2010/12/24 06:00
MHDA- 2011/06/11 06:00
PMCR- 2012/03/01
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/06/11 06:00 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - bjq120 [pii]
AID - 10.1093/chemse/bjq120 [doi]
PST - ppublish
SO  - Chem Senses. 2011 Mar;36(3):251-60. doi: 10.1093/chemse/bjq120. Epub 2010 Dec 21.