PMID- 2117774
OWN - NLM
STAT- MEDLINE
DCOM- 19900926
LR  - 20191022
IS  - 0387-821X (Print)
IS  - 0387-821X (Linking)
VI  - 12
IP  - 2
DP  - 1990 Jun 1
TI  - Antiviral and antiproliferative activities of recombinant human interferon alpha 
      2, beta and gamma on HTLV-I and ATL cells in vitro.
PG  - 149-61
AB  - ATL (Adult T cell leukemia) causes severe immune deficiency. Furthermore, 
      aggravation of immune deficiency is a major problem in chemotherapy of ATL. In 
      expectation of antiviral, antineoplastic and increasing immunological activity, 
      several clinical trials of Interferons (IFNs) on ATL have been reported. However, 
      as the effects have not been generally established, we investigated the in vitro 
      effects of human recombinant interferon (rIFN) alpha 2, beta and gamma on both 
      the infection of human T-cell lymphotropic virus type I (HTLV-I) to normal 
      peripheral blood lymphocytes (PBL) and the growth of ATL cells. The induction of 
      HTLV-I specific antigens on the surface of normal PBL cultured with HTLV-I in 
      vitro was inhibited by the addition of rIFNs in a dose dependent manner. The 
      rIFNs also had dose dependent suppressive effects on the proliferation of ATL 
      cells and one of the ATL cell lines (MT-2). These suppressive effects of rIFNs 
      were not due to a direct cytocidal activity, because rIFNs did not affect the 
      viability of ATL cells at these concentrations. Such inhibitory concentrations (1 
      to 1000 U/ml) were within the ranges achievable in the blood of patients after 
      the injection of rIFNs. This investigation suggests that rIFNs is applicable for 
      the therapy of ATL.
FAU - Koyama, Y
AU  - Koyama Y
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, Kitakyushu, Japan.
FAU - Tanaka, Y
AU  - Tanaka Y
FAU - Oda, S
AU  - Oda S
FAU - Yamashita, U
AU  - Yamashita U
FAU - Eto, S
AU  - Eto S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J UOEH
JT  - Journal of UOEH
JID - 7909645
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Antiviral Agents)
RN  - 0 (HTLV-I Antigens)
RN  - 0 (Interferon Type I)
RN  - 0 (Recombinant Proteins)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - *Antineoplastic Agents
MH  - *Antiviral Agents
MH  - Cell Division
MH  - Cell Survival
MH  - HTLV-I Antigens/analysis
MH  - Human T-lymphotropic virus 1/immunology/*pathogenicity
MH  - Humans
MH  - Interferon Type I/*pharmacology
MH  - Interferon-gamma/*pharmacology
MH  - Leukemia-Lymphoma, Adult T-Cell/*pathology
MH  - Lymphocytes/immunology/microbiology
MH  - Recombinant Proteins
MH  - Tumor Cells, Cultured/pathology
EDAT- 1990/06/01 00:00
MHDA- 1990/06/01 00:01
CRDT- 1990/06/01 00:00
PHST- 1990/06/01 00:00 [pubmed]
PHST- 1990/06/01 00:01 [medline]
PHST- 1990/06/01 00:00 [entrez]
AID - 10.7888/juoeh.12.149 [doi]
PST - ppublish
SO  - J UOEH. 1990 Jun 1;12(2):149-61. doi: 10.7888/juoeh.12.149.