PMID- 21179106
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20220318
IS  - 1435-232X (Electronic)
IS  - 1434-5161 (Linking)
VI  - 56
IP  - 3
DP  - 2011 Mar
TI  - Association of HLA-A*02:06 and HLA-DRB1*04:05 with clinical subtypes of juvenile 
      idiopathic arthritis.
PG  - 196-9
LID - 10.1038/jhg.2010.159 [doi]
AB  - Juvenile idiopathic arthritis (JIA) is one of the most common forms of pediatric 
      chronic arthritis. JIA is a clinically heterogeneous disease. Therefore, the 
      genetic background of JIA may also be heterogeneous. The aim of this study was to 
      investigate associations between human leukocyte antigen (HLA) and susceptibility 
      to JIA and/or uveitis, which is one of the most devastating complications of JIA. 
      A total of 106 Japanese articular JIA patients (67 with polyarthritis and 39 with 
      oligoarthritis) and 678 healthy controls were genotyped for HLA-A, -B and -DRB1 
      by PCR-sequence-specific oligonucleotide probe methodology. HLA-A(*)02:06 was the 
      risk factor for JIA accompanied by uveitis after adjustment for clinical factors 
      (corrected P-value < 0.001, odds ratio (OR) 11.7, 95% confidence interval (CI) 
      3.2-43.0). On the other hand, HLA-DRB1(*)04:05 was associated with polyarticular 
      JIA (corrected P-value < 0.001, OR 2.9, 95% CI 1.7-4.8). We found an association 
      of HLA-A(*)02:06 with susceptibility to JIA accompanied by uveitis, which might 
      be considered a separate clinical JIA entity. We also found an association 
      between HLA-DRB1(*)04:05 and polyarticular JIA. Thus, clinical subtypes of JIA 
      can be classified by the presence of the specific HLA alleles, HLA-A(*)02:06 and 
      DRB1(*)04:05.
FAU - Yanagimachi, Masakatsu
AU  - Yanagimachi M
AD  - Department of Pediatrics, Yokohama City University Graduate School of Medicine, 
      Yokohama, Japan.
FAU - Miyamae, Takako
AU  - Miyamae T
FAU - Naruto, Takuya
AU  - Naruto T
FAU - Hara, Takuma
AU  - Hara T
FAU - Kikuchi, Masako
AU  - Kikuchi M
FAU - Hara, Ryoki
AU  - Hara R
FAU - Imagawa, Tomoyuki
AU  - Imagawa T
FAU - Mori, Masaaki
AU  - Mori M
FAU - Kaneko, Tetsuji
AU  - Kaneko T
FAU - Goto, Hiroaki
AU  - Goto H
FAU - Morita, Satoshi
AU  - Morita S
FAU - Mizuki, Nobuhisa
AU  - Mizuki N
FAU - Kimura, Akinori
AU  - Kimura A
FAU - Yokota, Shumpei
AU  - Yokota S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101223
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Arthritis, Juvenile/complications/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-A Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Uveitis/complications/genetics
EDAT- 2010/12/24 06:00
MHDA- 2011/07/16 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - jhg2010159 [pii]
AID - 10.1038/jhg.2010.159 [doi]
PST - ppublish
SO  - J Hum Genet. 2011 Mar;56(3):196-9. doi: 10.1038/jhg.2010.159. Epub 2010 Dec 23.