PMID- 21179117
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20111117
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Linking)
VI  - 12
IP  - 3
DP  - 2011 Apr
TI  - HLA (A-B-C and -DRB1) alleles and brain MRI changes in multiple sclerosis: a 
      longitudinal study.
PG  - 183-90
LID - 10.1038/gene.2010.58 [doi]
AB  - Several major histocompatibility complex (MHC) alleles have been postulated to 
      influence the susceptibility to multiple sclerosis (MS), as well as its 
      clinical/radiological course. In this longitudinal observation, we further 
      explored the impact of human leukocyte antigen (HLA) class I/II alleles on MS 
      outcomes, and we tested the hypothesis that HLA DRB1*1501 might uncover different 
      strata of MS subjects harboring distinct MHC allele associations with magnetic 
      resonance imaging (MRI) measures. Five hundred eighteen MS patients with 
      two-digit HLA typing and at least one brain MRI were recruited for the study. 
      T2-weighted hyperintense lesion volume (T2LV) and brain parenchymal fraction 
      (BPF) were acquired at each time point. The association between allele count and 
      MRI values was determined using linear regression modeling controlling for age, 
      disease duration and gender. Analyses were also stratified by the 
      presence/absence of HLA DRB1*1501. HLA DRB1*04 was associated with higher T2LV 
      (P=0.006); after stratification, its significance remained only in the presence 
      of HLA DRB1*1501 (P=0.012). The negative effect of HLA DRB1*14 on T2LV was 
      exerted in DRB1*1501-negative group (P=0.012). Longitudinal analysis showed that 
      HLA DRB1*10 was significantly protective on T2LV accrual in the presence of HLA 
      DRB1*1501 (P=0.002). Although the majority of our results did not withstand 
      multiple comparison correction, the differential impact of several HLA alleles in 
      the presence/absence of HLA DRB1*1501 suggests that they may interact in 
      determining the different phenotypic expressions of MS.
FAU - Liguori, M
AU  - Liguori M
AD  - Center for Neurological Imaging, Department of Radiology, Brigham and Women's 
      Hospital, Harvard Medical School, Boston, MA 02115, USA.
FAU - Healy, B C
AU  - Healy BC
FAU - Glanz, B I
AU  - Glanz BI
FAU - Khoury, S J
AU  - Khoury SJ
FAU - Moscufo, N
AU  - Moscufo N
FAU - Weiner, H L
AU  - Weiner HL
FAU - De Jager, P L
AU  - De Jager PL
FAU - Guttmann, C R
AU  - Guttmann CR
LA  - eng
PT  - Journal Article
DEP - 20101223
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*15:01 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Brain/*pathology
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/genetics
MH  - HLA Antigens/*genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Longitudinal Studies
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*genetics/*pathology
MH  - Young Adult
EDAT- 2010/12/24 06:00
MHDA- 2011/10/05 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
AID - gene201058 [pii]
AID - 10.1038/gene.2010.58 [doi]
PST - ppublish
SO  - Genes Immun. 2011 Apr;12(3):183-90. doi: 10.1038/gene.2010.58. Epub 2010 Dec 23.