PMID- 21179302
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1949-8462 (Electronic)
IS  - 1949-8462 (Print)
VI  - 2
IP  - 11
DP  - 2010 Nov 26
TI  - Role of dendritic cells in cardiovascular diseases.
PG  - 357-64
LID - 10.4330/wjc.v2.i11.357 [doi]
AB  - Dendritic cells (DCs) are potent antigen-presenting cells that bridge innate and 
      adaptive immune responses. Recent work has elucidated the DC life cycle, 
      including several important stages such as maturation, migration and homeostasis, 
      as well as DC classification and subsets/locations, which provided etiological 
      insights on the role of DCs in disease processes. DCs have a close relationship 
      to endothelial cells and they interact with each other to maintain immunity. DCs 
      are deposited in the atherosclerotic plaque and contribute to the pathogenesis of 
      atherosclerosis. In addition, the necrotic cardiac cells induced by ischemia 
      activate DCs by Toll-like receptors, which initiate innate and adaptive immune 
      responses to renal, hepatic and cardiac ischemia reperfusion injury (IRI). 
      Furthermore, DCs are involved in the acute/chronic rejection of solid organ 
      transplantation and mediate transplant tolerance as well. Advancing our knowledge 
      of the biology of DCs will aid development of new approaches to treat many 
      cardiovascular diseases, including atherosclerosis, cardiac IRI and 
      transplantation.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Yi Zhang, Cuihua Zhang, Department of Internal Medicine, Medical Pharmacology and 
      Physiology and Nutritional Sciences, Dalton Cardiovascular Research Center, 
      University of Missouri, Columbia, MO 65211, United States.
FAU - Zhang, Cuihua
AU  - Zhang C
LA  - eng
GR  - R01 HL077566/HL/NHLBI NIH HHS/United States
GR  - R01 HL085119/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - World J Cardiol
JT  - World journal of cardiology
JID - 101537090
PMC - PMC3006471
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Dendritic cells
OT  - Ischemia reperfusion
OT  - Transplantation
EDAT- 2010/12/24 06:00
MHDA- 2010/12/24 06:01
PMCR- 2010/11/26
CRDT- 2010/12/24 06:00
PHST- 2010/08/02 00:00 [received]
PHST- 2010/10/24 00:00 [revised]
PHST- 2010/10/31 00:00 [accepted]
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2010/12/24 06:01 [medline]
PHST- 2010/11/26 00:00 [pmc-release]
AID - 10.4330/wjc.v2.i11.357 [doi]
PST - ppublish
SO  - World J Cardiol. 2010 Nov 26;2(11):357-64. doi: 10.4330/wjc.v2.i11.357.