PMID- 21179727
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 30
IP  - 9
DP  - 2010 Sep
TI  - [Retrospective study on Chinese medicine syndrome patterns and their associated 
      factors in patients with type 2 diabetic nephropathy stage III].
PG  - 915-8
AB  - OBJECTIVE: To explore the relationship between Chinese medicine syndrome patterns 
      (CMSP) and their associated factors in patients with type 2 diabetic nephropathy 
      stage III (DN2-3). METHODS: Retrospective analysis was conducted on 209 patients 
      with type 2 diabetes mellitus (T2DM). The patients were allocated into two 
      groups, the DN2-3 group and the control group. Some related clinical materials 
      and laboratory indexes, including age, course of disease, body mass index (BMI), 
      glycosylated hemoglobin A1c (HbA1c), systolic blood pressure (SBP), diastolic 
      blood pressure (DBP), blood levels of total cholesterol (TC), triglyceride (TG), 
      high and low density lipoprotein (HDL and LDL), serum creatinine (Scr) and 
      microalbuminuria (MALB) as well as their CMSP (both the essential syndrome and 
      the superficial syndrome) in the DN2-3 group were collected and compared. 
      RESULTS: Significant differences were found between the DN2-3 group and the 
      control group in aspects of course of disease (months, 107.74 +/- 96.19 vs. 82.03 
      +/- 79.10), BMI (kg/m2, 26.25 +/- 4.02 vs. 24.95 +/- 3.56) and Scr level (mmoL/L, 
      71.93 +/- 24.24 vs. 65.91 +/- 13.70, P < 0.05). The qi-yin deficiency SP (38 
      cases, 36.19%), and the blood stasis (51 cases, 48.58%) presented as the dominant 
      essential and superficial CM-SP respectively in DN2-3 patients, holding the 
      highest proportion. Analysis on the relationship of associated indices among 
      patients with different CMSP showed statistical differences presented in level of 
      MALB, i.e. which in pi-shen qi-deficiency SP (128.77 +/- 103.59 mg/24 h) was 
      higher than in yin-deficiency dryness-fire SP and qi-yin deficiency SP (88.43 +/- 
      68.93 mg/24h and 82.60 +/- 55.22 mg/24 h, P < 0.05); it also presented in HbA1c 
      (%) and TG levels(mmol/L), those in stasis SP were 10.73 +/- 2.71 and 2.29 +/- 
      1.58 ), in dampness SP were 8.80 +/- 2.19% and 4.37 +/- 5.92, and in 
      stasis-phlegm SP were 8.83 +/- 2.09 and 2.40 +/- 2.18 (all P < 0.05). 
      CONCLUSIONS: The risk factors for occurrence of DN2-3 may be the course of 
      disease, BMI and Scr. Qi-yin deficiency with blood-stasis is the most commonly 
      encountered syndrome in patients with DN2-3. Relations of MALB with Pi-Shen 
      qi-deficiency pattern; HbA1c with blood-stasis pattern, and TG with dampness 
      syndrome are distinctly exhibited in them.
FAU - Zhang, Guang-De
AU  - Zhang GD
AD  - Department of Endocrinology, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences, Beijing.
FAU - Zou, Ben-Liang
AU  - Zou BL
FAU - Meng, Hui
AU  - Meng H
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Albuminuria/physiopathology
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Diabetic Nephropathies/*physiopathology
MH  - *Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Male
MH  - *Medicine, Chinese Traditional
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2010/12/25 06:00
MHDA- 2013/02/05 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Sep;30(9):915-8.