PMID- 21180027
OWN - NLM
STAT- MEDLINE
DCOM- 20110125
LR  - 20181201
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 62
IP  - 1
DP  - 2010 Jan-Feb
TI  - Bisoprolol and heart failure: new frontiers.
PG  - 7-12
AB  - Clinical trials have consistently shown the benefits of beta-blocker treatment in 
      patients with chronic heart failure (HF). As a result, bisoprolol, carvedilol, 
      and metoprolol succinate are now indicated for the treatment of all patients with 
      chronic HF who do not have major contraindications. In the Cardiac Insufficiency 
      Bisoprolol Study II (CIBIS-II), all-cause mortality and sudden death were reduced 
      in patients treated with bisoprolol when compared with those on placebo (11.8% 
      vs. 17.3%; p < 0.0001 and 3.6% vs. 6.3%, p < 0.002; respectively) regardless of 
      age, New York Heart Association (NYHA) functional class and co-morbidities. More 
      recently, CIBIS-III has shown similar efficacy and safety of the initiation of HF 
      treatment with either bisoprolol or enalapril, with a tendency to a survival 
      advantage with bisoprolol. Nowadays, the role of bisoprolol, as well as that of 
      carvedilol and metoprolol succinate, in HF treatment is firmly established and 
      research is mainly focused on implementation of treatment and better dosing. This 
      article will summarize evidence for the efficacy of bisoprolol in the treatment 
      of HF.
FAU - Chopra, H K
AU  - Chopra HK
LA  - eng
PT  - Comparative Study
PT  - Editorial
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
RN  - 0 (Adrenergic beta-1 Receptor Antagonists)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Carbazoles)
RN  - 0 (Propanolamines)
RN  - 0K47UL67F2 (Carvedilol)
RN  - GEB06NHM23 (Metoprolol)
RN  - Y41JS2NL6U (Bisoprolol)
SB  - IM
MH  - Adrenergic beta-1 Receptor Antagonists/administration & dosage/*therapeutic use
MH  - Antihypertensive Agents/administration & dosage/*therapeutic use
MH  - Bisoprolol/administration & dosage/*therapeutic use
MH  - Carbazoles/administration & dosage/therapeutic use
MH  - Carvedilol
MH  - Heart Failure/*drug therapy
MH  - Metoprolol/administration & dosage/therapeutic use
MH  - Multicenter Studies as Topic
MH  - Propanolamines/administration & dosage/therapeutic use
MH  - Randomized Controlled Trials as Topic
EDAT- 2010/12/25 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
PST - ppublish
SO  - Indian Heart J. 2010 Jan-Feb;62(1):7-12.