PMID- 21180468
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0975-7406 (Electronic)
IS  - 0976-4879 (Print)
IS  - 0975-7406 (Linking)
VI  - 2
IP  - 4
DP  - 2010 Oct
TI  - Assessment of asthma and chronic obstructive pulmonary disorder in relation to 
      reversibility, IgE, eosinophil, and neutrophil count in a University Teaching 
      Hospital in South Delhi, India.
PG  - 337-40
LID - 10.4103/0975-7406.72136 [doi]
AB  - OBJECTIVES: The physiological and clinical similarities between asthma and 
      chronic obstructive pulmonary disorder (COPD) make their differentiation 
      difficult. In the present study, we compared reversibility to bronchodilator, 
      immunoglobulin E (IgE), blood eosinophil and neutrophil levels among asthma and 
      COPD patients to differentiate these diseases. MATERIALS AND METHODS: The study 
      was carried on 20 asthmatics and 29 patients of COPD that reported to the 
      outpatient and inpatient department in University Teaching Hospital, Jamia 
      Hamdard, New Delhi, India. The parameters evaluated included pulmonary function 
      (FEV(1), FVC, and FEV(1)/FVC), IgE levels, and eosinophil and neutrophil count. 
      RESULTS: It was observed that reversibility was significantly higher in asthmatic 
      patients, while irreversibility predominates in COPD patients. There was no 
      significant difference in pre- and post-FEV(1) and pre- and post-FVC and in their 
      percentage predicted. However the percentage change in FEV(1) significantly 
      varies in asthma and COPD patients. No significant changes in neutrophil and 
      eosinophil levels were observed in these patients. The serum IgE levels were 
      found significantly higher in asthmatic patients. CONCLUSIONS: We conclude that 
      reversibility in FEV(1) levels or percentage change in FEV(1) and serum IgE 
      levels are promising lab parameter to distinguish these two conditions. However, 
      further research is required to fully understand the role of neutrophil and 
      eosinophil in the onset and development of asthma and COPD.
FAU - Rathod, Virender P Singh
AU  - Rathod VP
AD  - Department of Pharmacology, Faculty of Pharmacy, Majeedia Hospital, Jamia Hamdard 
      University, New Delhi - 110 062, India.
FAU - Kapoor, Prem
AU  - Kapoor P
FAU - Pillai, K K
AU  - Pillai KK
FAU - Khanam, Razia
AU  - Khanam R
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Pharm Bioallied Sci
JT  - Journal of pharmacy & bioallied sciences
JID - 101537209
PMC - PMC2996067
OTO - NOTNLM
OT  - Asthma
OT  - bronchodilator
OT  - chronic obstructive pulmonary disorder
OT  - eosinophil
OT  - immunoglobulin E
OT  - neutrophil
COIS- Conflict of Interest: None declared.
EDAT- 2010/12/25 06:00
MHDA- 2010/12/25 06:01
PMCR- 2010/10/01
CRDT- 2010/12/25 06:00
PHST- 2010/05/01 00:00 [received]
PHST- 2010/06/11 00:00 [revised]
PHST- 2010/08/03 00:00 [accepted]
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2010/12/25 06:01 [medline]
PHST- 2010/10/01 00:00 [pmc-release]
AID - JPBS-2-337 [pii]
AID - 10.4103/0975-7406.72136 [doi]
PST - ppublish
SO  - J Pharm Bioallied Sci. 2010 Oct;2(4):337-40. doi: 10.4103/0975-7406.72136.