PMID- 21181302 OWN - NLM STAT- MEDLINE DCOM- 20120430 LR - 20211020 IS - 1559-0267 (Electronic) IS - 1080-0549 (Linking) VI - 41 IP - 3 DP - 2011 Dec TI - Role of dendritic cells in atopic dermatitis: an update. PG - 254-8 LID - 10.1007/s12016-010-8224-0 [doi] AB - Dendritic cells (DCs) have been recognized as key players bridging innate and adaptive immune systems. They control the balance of the adaptive immune response, and the functional behavior of DCs is mainly dictated by their microenvironment. Atopic dermatitis (AD) is a paradigmatic disease where the inflammatory microenvironment has a deep impact on DCs. The emergence of IgE-mediated sensitization is tightly related to the impact of locally released cytokines by either keratinocytes, T cells, or other cells involved in the inflammatory reaction. This review will focus on the recent and relevant findings in the field of immunobiology of DCs and their role in AD. FAU - Bieber, Thomas AU - Bieber T AD - Department of Dermatology and Allergy, University of Bonn Medical Center, Germany. Thomas.Bieber@ukb.uni-bonn.de FAU - Novak, Natalija AU - Novak N FAU - Herrmann, Nadine AU - Herrmann N FAU - Koch, Susanne AU - Koch S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - United States TA - Clin Rev Allergy Immunol JT - Clinical reviews in allergy & immunology JID - 9504368 SB - IM EIN - Clin Rev Allergy Immunol. 2011 Dec;41(3):311. Herrman, Nadine [corrected to Herrmann, Nadine] MH - Adaptive Immunity MH - Animals MH - Dendritic Cells/*immunology/metabolism MH - Dermatitis, Atopic/*immunology/physiopathology/therapy MH - Humans MH - Immunity, Innate MH - Myeloid Cells/immunology/metabolism EDAT- 2010/12/25 06:00 MHDA- 2012/05/01 06:00 CRDT- 2010/12/25 06:00 PHST- 2010/12/25 06:00 [entrez] PHST- 2010/12/25 06:00 [pubmed] PHST- 2012/05/01 06:00 [medline] AID - 10.1007/s12016-010-8224-0 [doi] PST - ppublish SO - Clin Rev Allergy Immunol. 2011 Dec;41(3):254-8. doi: 10.1007/s12016-010-8224-0.