PMID- 21181474
OWN - NLM
STAT- MEDLINE
DCOM- 20110620
LR  - 20211020
IS  - 1432-2323 (Electronic)
IS  - 0364-2313 (Linking)
VI  - 35
IP  - 3
DP  - 2011 Mar
TI  - Laparoscopic organ-sparing resection of von Hippel-Lindau disease-associated 
      pancreatic neuroendocrine tumors.
PG  - 563-7
LID - 10.1007/s00268-010-0878-5 [doi]
AB  - BACKGROUND: Pancreatic neuroendocrine tumors (PNETs) are a characteristic feature 
      of the tumor syndromes multiple endocrine neoplasia type 1 (MEN-1) and von 
      Hippel-Lindau disease (VHL). With VHL, about 10% of the patients exhibit PNETs by 
      age 40 years. Metastatic potential is high if the tumors have grown to >3 cm in 
      diameter. Optimal surgical treatment is still a challenge. METHODS: We report 
      three cases, all women, ages 22, 30, and 39 years, respectively, who had known 
      VHL, confirmed by classic organ manifestations and germline mutations of the VHL 
      gene. All were diagnosed, in an asymptomatic stage, with solid tumors of the 
      pancreatic tail or tail/corpus area measuring 2.9-5.6 cm diameter. All accepted 
      the offer of laparoscopic organ-sparing removal of the tumors. RESULTS: In all 
      three cases, the tumor was entirely removed. In two cases, resection of the 
      spleen was also necessary as dissection of the tumor from the major splenic 
      vessels was impossible. Operating time was 215-365 min, and blood loss was 
      200-700 ml. Histolopathology revealed benign PNETs in two cases, but the third 
      patient had regional lymph node metastases. There were no complications, and the 
      hospital stay was 4-7 days. CONCLUSIONS: Organ-sparing laparoscopic surgery is an 
      important option for treating VHL-associated PNETs of the pancreatic tail.
FAU - von Ducker, Laura
AU  - von Ducker L
AD  - Department of Nephrology and General Medicine, University Medical Center, Albert 
      Ludwigs University, Hugstetter Strasse 55, 79106 Freiburg, Germany.
FAU - Walz, Martin K
AU  - Walz MK
FAU - Voss, Christian
AU  - Voss C
FAU - Arnold, Georg
AU  - Arnold G
FAU - Eng, Charis
AU  - Eng C
FAU - Neumann, Hartmut P H
AU  - Neumann HP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Surg
JT  - World journal of surgery
JID - 7704052
SB  - IM
MH  - Adult
MH  - Biopsy, Needle
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunohistochemistry
MH  - Laparoscopy/*methods
MH  - Magnetic Resonance Imaging/methods
MH  - Minimally Invasive Surgical Procedures/methods
MH  - Neuroendocrine Tumors/complications/diagnosis/*surgery
MH  - Pancreatectomy/methods
MH  - Pancreatic Neoplasms/complications/diagnosis/*surgery
MH  - Risk Assessment
MH  - Sampling Studies
MH  - Treatment Outcome
MH  - von Hippel-Lindau Disease/complications/diagnosis/*surgery
EDAT- 2010/12/25 06:00
MHDA- 2011/06/21 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/06/21 06:00 [medline]
AID - 10.1007/s00268-010-0878-5 [doi]
PST - ppublish
SO  - World J Surg. 2011 Mar;35(3):563-7. doi: 10.1007/s00268-010-0878-5.