PMID- 21182967
OWN - NLM
STAT- MEDLINE
DCOM- 20110610
LR  - 20110208
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 55
IP  - 2
DP  - 2011 Mar 15
TI  - fMRI item analysis in a theory of mind task.
PG  - 705-12
LID - 10.1016/j.neuroimage.2010.12.040 [doi]
AB  - Conventional analyses of functional magnetic resonance imaging (fMRI) data 
      compare the brain's response to stimulus categories (e.g., pictures of faces, 
      stories about beliefs) across participants. In order to infer that effects 
      observed with the specific items (a particular set of pictures or stories) are 
      generalizable to the entire population (all faces, or all stories about beliefs), 
      it is necessary to perform an "item analysis." Item analyses may also reveal 
      relationships between secondary (non-hypothesized) features of the items and 
      functional activity. Here, we perform an item analysis on a set of stories 
      commonly used for localizing brain regions putatively involved in Theory of Mind 
      (ToM): right and left temporo-parietal junction (RTPJ/LTPJ), precuneus (PC), 
      superior temporal sulcus (STS) and medial prefrontal cortex (MPFC). We address 
      the following questions: Do brain regions that comprise the ToM network respond 
      reliably across items (i.e. different stories about beliefs)? Do these brain 
      regions demonstrate reliable preferences for items within the category? Can we 
      predict any region's response to individual items, by using other features of the 
      stimuli? We find that the ToM network responds reliably to stories about beliefs, 
      generalizing across items as well as subjects. In addition, several regions in 
      the ToM network have reliable preferences for individual items. Linguistic 
      features of the stimuli did not predict these item preferences.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Dodell-Feder, David
AU  - Dodell-Feder D
AD  - Department of Psychology, Harvard University, Cambridge, MA 02138, USA. 
      feder@fas.harvard.edu
FAU - Koster-Hale, Jorie
AU  - Koster-Hale J
FAU - Bedny, Marina
AU  - Bedny M
FAU - Saxe, Rebecca
AU  - Saxe R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20101221
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/*physiology
MH  - *Brain Mapping
MH  - Culture
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - Linguistics
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Theory of Mind/*physiology
MH  - Young Adult
EDAT- 2010/12/25 06:00
MHDA- 2011/06/11 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/08/06 00:00 [received]
PHST- 2010/12/08 00:00 [revised]
PHST- 2010/12/13 00:00 [accepted]
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/06/11 06:00 [medline]
AID - S1053-8119(10)01624-1 [pii]
AID - 10.1016/j.neuroimage.2010.12.040 [doi]
PST - ppublish
SO  - Neuroimage. 2011 Mar 15;55(2):705-12. doi: 10.1016/j.neuroimage.2010.12.040. Epub 
      2010 Dec 21.