PMID- 21183233
OWN - NLM
STAT- MEDLINE
DCOM- 20130214
LR  - 20161125
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 157
IP  - 1
DP  - 2012 May 17
TI  - Echocardiography for assessment of regional and global right ventricular systolic 
      function in adults with repaired tetralogy of Fallot.
PG  - 53-8
LID - 10.1016/j.ijcard.2010.11.017 [doi]
AB  - BACKGROUND: The right ventricular (RV) systolic function is important for 
      decision making in adults with repaired tetralogy of Fallot (rTOF). Our aim was 
      to assess regional RV systolic function and its impact on global RV systolic 
      function by echocardiography. METHODS: In 101 adults with rTOF, regional RV 
      systolic function on echocardiography was compared to 50 individuals with 
      structurally normal hearts. In patients with rTOF, the impact of 
      echocardiographic measures of regional RV systolic function on global RV-ejection 
      fraction as measured by cardiac magnetic resonance imaging (CMR-RVEF) was 
      determined. RESULTS: Compared to normals, patients with rTOF had impaired 
      systolic function of the RV outflow tract. Patients with rTOF and normal CMR-RVEF 
      compensate this loss of RV outflow tract function with increased contractions of 
      the RV-body, measured as fractional area change on short axis (30+/-12% versus 
      19+/-7%, p<0.0001) and on 4-chamber views (42+/-7% versus 38+/-8%, p=0.06). In 
      contrast, patients with rTOF and abnormal global CMR-RVEF showed significantly 
      lower systolic function of the RV-body compared to normal controls (fractional 
      area change on 4-chamber view: 31+/-6% versus 38+/-8%, p<0.0001). A simple regression 
      model, incorporating fractional shortening of RV outflow tract and fractional 
      area change on 4-chamber view allows accurate echocardiographic estimation of the 
      CMR-derived RVEF. CONCLUSIONS: Patients with repaired tetralogy of Fallot have 
      markedly different regional systolic RV-function compared to normals, even when 
      the global RV systolic function is preserved. The systolic function of the RV 
      outflow tract and of the RV body are both important determinants of global 
      systolic RV function in these patients. Their prognostic significance needs to be 
      determined.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Greutmann, Matthias
AU  - Greutmann M
AD  - University hospital of Zurich, Raemis, Zurich, Switzerland. 
      Matthias.Greutmann@usz.ch
FAU - Tobler, Daniel
AU  - Tobler D
FAU - Biaggi, Patric
AU  - Biaggi P
FAU - Mah, May Ling
AU  - Mah ML
FAU - Crean, Andrew
AU  - Crean A
FAU - Wald, Rachel M
AU  - Wald RM
FAU - Silversides, Candice K
AU  - Silversides CK
FAU - Oechslin, Erwin N
AU  - Oechslin EN
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20101222
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Adult
MH  - *Echocardiography/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Tetralogy of Fallot/*diagnostic imaging/physiopathology/*surgery
MH  - Ventricular Dysfunction, Right/*diagnostic imaging/physiopathology
MH  - Ventricular Function, Right/*physiology
MH  - Young Adult
EDAT- 2010/12/25 06:00
MHDA- 2013/02/15 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/09/24 00:00 [received]
PHST- 2010/10/23 00:00 [revised]
PHST- 2010/11/29 00:00 [accepted]
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2013/02/15 06:00 [medline]
AID - S0167-5273(10)01036-3 [pii]
AID - 10.1016/j.ijcard.2010.11.017 [doi]
PST - ppublish
SO  - Int J Cardiol. 2012 May 17;157(1):53-8. doi: 10.1016/j.ijcard.2010.11.017. Epub 
      2010 Dec 22.