PMID- 21184821
OWN - NLM
STAT- MEDLINE
DCOM- 20111107
LR  - 20181201
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 134
IP  - 2
DP  - 2011 Mar 24
TI  - Inhibition of 2,4-dinitrofluorobenzene-induced atopic dermatitis by topical 
      application of the butanol extract of Cordyceps bassiana in NC/Nga mice.
PG  - 504-9
LID - 10.1016/j.jep.2010.12.012 [doi]
AB  - ETHNOPHARMACOLOGICAL SIGNIFICANCE: The Cordyceps species are insect-borne 
      mushrooms that have been ethnopharmacologically used for skin diseases such as 
      eczema and dermatitis. AIM OF THE STUDY: In this study, we investigated the 
      curative effects of the butanol fraction (CBBF) of Cordyceps bassiana on atopic 
      dermatitis. MATERIALS AND METHODS: Dermatitis was induced by repeated application 
      of 2,4-dinitrofluorobenzene (DNFB) in NC/Nga mice. After a topical application of 
      CBBF on the skin lesions, the dermatitis score, epidermal thickness, mast cell 
      number, and interleukin (IL)-4 and interferon (IFN)-gamma, as well as the levels of 
      histamine and immunoglobulin E (IgE) in the serum, were measured. Moreover, 
      effect of CBBF on histamine release was examined using RBL-2H3 under stimulation 
      with 2,4-dinitrophenylated bovine serum albumin (DNP-BSA). RESULTS: CBBF 
      inhibited atopic dermatitis symptoms and signs in the DNFB-treated NC/Nga mice. 
      The suppressive activity of topically applied CBBF may be due to the 
      dose-dependent blockade of a series of immunopathological events, including the 
      release of histamine, the production of IgE, and the secretion of IL-4 and IFN-gamma. 
      However, this extract did not directly suppress the degranulation process, 
      assessed by measuring beta-hexosaminidase release. CONCLUSIONS: Our results suggest 
      that CBBF can be applied as an effective herbal remedy to treat atopic 
      dermatitis.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Wu, Guang
AU  - Wu G
AD  - Department of Physiology, College of Medicine, Hallym University, 39 
      Hallymdaehak-gil, Chuncheon 200-702, Republic of Korea.
FAU - Li, Lan
AU  - Li L
FAU - Sung, Gi Ho
AU  - Sung GH
FAU - Kim, Tae Woong
AU  - Kim TW
FAU - Byeon, Se Eun
AU  - Byeon SE
FAU - Cho, Jae Youl
AU  - Cho JY
FAU - Park, Chun Wook
AU  - Park CW
FAU - Park, Hyoung Jin
AU  - Park HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101222
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Biological Products)
RN  - 0 (Immunologic Factors)
RN  - 0 (Serum Albumin)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
RN  - 82115-62-6 (Interferon-gamma)
RN  - D241E059U6 (Dinitrofluorobenzene)
RN  - EC 3.2.1.52 (beta-N-Acetylhexosaminidases)
SB  - IM
MH  - Administration, Topical
MH  - Animals
MH  - Biological Products/pharmacology/*therapeutic use
MH  - Cattle
MH  - Cell Degranulation/drug effects
MH  - *Cordyceps/chemistry
MH  - Dermatitis, Atopic/*drug therapy/immunology/pathology
MH  - Dinitrofluorobenzene
MH  - Dose-Response Relationship, Drug
MH  - Epidermis/drug effects/pathology
MH  - Histamine/metabolism
MH  - Immunoglobulin E/biosynthesis
MH  - Immunologic Factors/*blood
MH  - Interferon-gamma/metabolism
MH  - Interleukin-4/metabolism
MH  - Male
MH  - Mast Cells/drug effects/metabolism
MH  - Mice
MH  - Mice, Inbred Strains
MH  - *Phytotherapy
MH  - Serum Albumin
MH  - Skin/*drug effects/immunology/pathology
MH  - beta-N-Acetylhexosaminidases/blood
EDAT- 2010/12/28 06:00
MHDA- 2011/11/08 06:00
CRDT- 2010/12/28 06:00
PHST- 2010/07/13 00:00 [received]
PHST- 2010/11/22 00:00 [revised]
PHST- 2010/12/08 00:00 [accepted]
PHST- 2010/12/28 06:00 [entrez]
PHST- 2010/12/28 06:00 [pubmed]
PHST- 2011/11/08 06:00 [medline]
AID - S0378-8741(10)00871-8 [pii]
AID - 10.1016/j.jep.2010.12.012 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2011 Mar 24;134(2):504-9. doi: 10.1016/j.jep.2010.12.012. Epub 
      2010 Dec 22.