PMID- 21185786
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20151119
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 138
IP  - 2
DP  - 2011 Feb
TI  - High level of soluble HLA-G in amniotic fluid is correlated with congenital 
      transmission of Toxoplasma gondii.
PG  - 129-34
LID - 10.1016/j.clim.2010.12.004 [doi]
AB  - The expression of human leukocyte antigen (HLA)-G on cytotrophoblast cells 
      contributes to maternal-fetal tolerance. Soluble forms of HLA-G (sHLA-G) can be 
      detected in amniotic fluid (AF) and a decrease of sHLA-G is known to be 
      correlated to fetal loss. In this work we investigated the role of sHLA-G in the 
      transplacental passage of the protozoan parasite Toxoplasma gondii, responsible 
      for congenital toxoplasmosis in about 30% of fetuses when primary infection (PI) 
      occurs during pregnancy. We determined the sHLA-G concentration in 61 AF from 
      women with PI and 24 controls. Our results showed higher sHLA-G levels in AF from 
      PI than in controls (p<0.001). Moreover sHLA-G level from congenitally infected 
      fetuses (n=12) was higher than in fetus in whom congenital infection was ruled 
      out (n=49, p<0.05). These data suggest that sHLA-G could participate in 
      immunomodulation necessary to avoid fetal loss due to Toxoplasma infection, but 
      that over-expression could favor congenital transmission.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Robert-Gangneux, Florence
AU  - Robert-Gangneux F
AD  - Laboratoire de Parasitologie, Faculte de Medecine et Centre Hospitalier 
      Universitaire de Rennes, Rennes, France. florence.robert-gangneux@univ-rennes1.fr
FAU - Gangneux, Jean-Pierre
AU  - Gangneux JP
FAU - Vu, Nicolas
AU  - Vu N
FAU - Jaillard, Sylvie
AU  - Jaillard S
FAU - Guiguen, Claude
AU  - Guiguen C
FAU - Amiot, Laurence
AU  - Amiot L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101224
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Interleukins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Amniotic Fluid/*immunology
MH  - Biomarkers/analysis
MH  - Female
MH  - HLA Antigens/*analysis/immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*analysis/immunology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - *Infectious Disease Transmission, Vertical
MH  - Interferon-gamma/analysis/immunology
MH  - Interleukins/analysis/immunology
MH  - Male
MH  - Pregnancy
MH  - Pregnancy Complications, Parasitic/*diagnosis
MH  - Retrospective Studies
MH  - Toxoplasma/*immunology/isolation & purification
MH  - Toxoplasmosis, Congenital/*diagnosis/transmission
MH  - Trophoblasts/immunology/parasitology
MH  - Tumor Necrosis Factor-alpha/analysis/immunology
EDAT- 2010/12/28 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/12/28 06:00
PHST- 2010/08/31 00:00 [received]
PHST- 2010/12/06 00:00 [revised]
PHST- 2010/12/06 00:00 [accepted]
PHST- 2010/12/28 06:00 [entrez]
PHST- 2010/12/28 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - S1521-6616(10)00779-5 [pii]
AID - 10.1016/j.clim.2010.12.004 [doi]
PST - ppublish
SO  - Clin Immunol. 2011 Feb;138(2):129-34. doi: 10.1016/j.clim.2010.12.004. Epub 2010 
      Dec 24.