PMID- 21186107
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20131121
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 22
IP  - 4
DP  - 2012 Apr
TI  - Nutritional intake and oxidative stress in chronic heart failure.
PG  - 376-82
LID - 10.1016/j.numecd.2010.08.006 [doi]
AB  - BACKGROUND AND AIMS: Patients with chronic heart failure (CHF) are known to be at 
      risk of malnutrition, and cardiac cachexia is an adverse prognostic indicator. 
      The aim of this study was to determine the dietary adequacy of CHF patients 
      compared with Dietary Reference Values, to compare the nutritional intake and 
      status of CHF patients to a healthy comparison group, and finally to determine 
      whether nutritional intake and status depended on New York Heart Association 
      (NYHA) functional class. METHODS AND RESULTS: Patients with CHF (n = 39) and a 
      comparison group of 27 healthy participants, who did not have CHF, were asked to 
      complete a four-day food diary, and energy and nutrient intakes were calculated. 
      F(2alpha)-isoprostanes were measured in urine as an indicator of oxidative stress and 
      antioxidants were measured in serum or plasma. Overall 73% of the CHF patients 
      were consuming less than recommended energy intakes, and more than 50% of these 
      patients were also consuming less than recommended vitamin D, selenium and zinc 
      intakes. Nutrient intake (energy, vitamin B6, D, E, iron, folate and riboflavin) 
      was lower in CHF patients than in the comparison group, with vitamin B6 and 
      folate intake and antioxidant status decreasing, and isoprostane status 
      increasing as NYHA functional class increased. CONCLUSION: The majority of CHF 
      patients do not meet dietary reference values for energy and a range of 
      nutrients, and nutrient intake is lower in CHF patients than in healthy 
      individuals. Dietary inadequacy tends to be increased in those with more severe 
      disease.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Hughes, C M
AU  - Hughes CM
AD  - Royal Victoria Hospital, Belfast Health and Social Care Trust, Grosvenor Road, 
      Belfast, BT12 6BA Northern Ireland, UK.
FAU - Woodside, J V
AU  - Woodside JV
FAU - McGartland, C
AU  - McGartland C
FAU - Roberts, M J
AU  - Roberts MJ
FAU - Nicholls, D P
AU  - Nicholls DP
FAU - McKeown, P P
AU  - McKeown PP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101224
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 8059-24-3 (Vitamin B 6)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - *Energy Intake
MH  - Female
MH  - Folic Acid/administration & dosage
MH  - Heart Failure/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Vitamin B 6/administration & dosage
EDAT- 2010/12/28 06:00
MHDA- 2012/07/24 06:00
CRDT- 2010/12/28 06:00
PHST- 2010/01/27 00:00 [received]
PHST- 2010/07/30 00:00 [revised]
PHST- 2010/08/18 00:00 [accepted]
PHST- 2010/12/28 06:00 [entrez]
PHST- 2010/12/28 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
AID - S0939-4753(10)00208-5 [pii]
AID - 10.1016/j.numecd.2010.08.006 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2012 Apr;22(4):376-82. doi: 
      10.1016/j.numecd.2010.08.006. Epub 2010 Dec 24.