PMID- 21186376
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20101227
IS  - 1205-7541 (Electronic)
IS  - 0008-4212 (Linking)
VI  - 89
IP  - 1
DP  - 2011 Jan
TI  - Coagulation activation in an experimental pneumonia model in malnourished mice.
PG  - 41-9
LID - 10.1139/y10-102 [doi]
AB  - Malnutrition induces a decrease in immunity that affects the ability of the 
      organism to deal with an infectious challenge. The clotting system is considered 
      a branch of immunity and its activation is important in the pathogenesis of an 
      infectious disease. This work was conducted to determine coagulation 
      modifications in malnourished hosts before and during infection. Weaned mice were 
      malnourished via a protein-free diet. Well-nourished control mice (WNC) consumed 
      a balanced conventional diet. Malnourished mice (MN) and WNC were challenged 
      intranasally with Streptococcus pneumoniae. Blood, bronchoalveolar lavages (BAL), 
      and lung samples were taken at different times post infection. The results were 
      that MN showed altered hemostatic tests and fibrin(ogen) deposits in the lung. 
      Thus, an increase in thrombin-antithrombin complexes (TATc) in plasma and BAL was 
      observed. In the MN group, infection induced a rise in TATc in plasma and BAL and 
      increased plasma fibrinogen and fibrin(ogen) deposits in the lung. A decrease in 
      activated protein C and antithrombin in BAL and an early decrease followed by an 
      increase in plasma Factor VIII were also observed. Thus, malnourishment induced a 
      procoagulant state increased by infection. This is the first work that presents 
      results of an exhaustive study of coagulation in malnourished hosts before and 
      during an infection.
FAU - Zelaya, Hortensia
AU  - Zelaya H
AD  - Universidad Nacional de Tucuman, San Miguel de Tucuman, Argentina.
FAU - Haro, Cecilia
AU  - Haro C
FAU - Laino, Jonathan
AU  - Laino J
FAU - Alvarez, Susana
AU  - Alvarez S
FAU - Aguero, Graciela
AU  - Aguero G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
SB  - IM
MH  - Animals
MH  - Blood Coagulation/*physiology
MH  - Bronchoalveolar Lavage Fluid/microbiology
MH  - *Disease Models, Animal
MH  - Hemostasis/physiology
MH  - Lung/blood supply/metabolism/microbiology
MH  - Male
MH  - Malnutrition/*blood/*complications/microbiology
MH  - Mice
MH  - Pneumonia, Pneumococcal/blood/*etiology/microbiology
MH  - Protein Deficiency/blood/*complications/microbiology
EDAT- 2010/12/28 06:00
MHDA- 2011/12/14 06:00
CRDT- 2010/12/28 06:00
PHST- 2010/12/28 06:00 [entrez]
PHST- 2010/12/28 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - y10-102 [pii]
AID - 10.1139/y10-102 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2011 Jan;89(1):41-9. doi: 10.1139/y10-102.