PMID- 21186598
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20161124
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 22
IP  - 1
DP  - 2006 Feb
TI  - [The effect of central histamine H3 receptor on breathing activity of asthmatic 
      guinea pigs].
PG  - 117-21
AB  - AIM: To investigate the effect of selective H3 receptor 
      agonist(R)-alpha-methylhistamine and antagonist thioperamide on the respiratory 
      response in asthmatic guinea pigs respectively. METHODS: Anesthesized guinea pigs 
      were prepared with a implanted intracerebroventricular (icv) cannula and 
      instrumented for the measurement of respiratory rate (RR) and diaphragmatic 
      electric activity (DA). Substance P-like immunoreactive (SP-LI) substances in 
      lower respiratory tract were detected by immunohistochemical method. Brain 
      histamine contents were measured by fluorometric determination. RESULTS: (1) 
      Intravenous injection of ovalbumin caused tachypnea and significant decrease in 
      DA magnitude. At the same time, SP-LI substances increased in trachea, bronchus 
      and lung. (2) Administration of selective H3 receptor agonist 
      (R)-alpha-methylhistamine (5 microg) icv immediately after i.v. ovalbumin could 
      significantly ameliorate the changes in RR and DA induced by ovalbumin. In 
      accordance, SP-LI substances in lower respiratory tract markedly decreased at 5 
      min and 10 min after (R)-alpha-methylhistamine microinjection. (3) Icv 
      thioperamide (20 microg) caused a significant increase in RR and a decrease in 
      DA. (4) Brain histamine contents increased in hypothalamus and cortex during 
      asthma. After microinjection of thioperamide (20 microg) icv significant increase 
      of histamine contents in hypothalamus and cortex was observed. CONCLUSION: Brain 
      histamine H3 receptors may be related to asthmatic respiratory responses.
FAU - Dong, Rong
AU  - Dong R
AD  - Department of Physiology, Medical College of Southeast University, Nanging 
      210009, China.
FAU - Zhang, Min
AU  - Zhang M
FAU - Lu, Bao-Shen
AU  - Lu BS
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - 0 (Histamine Agonists)
RN  - 0 (Histamine H3 Antagonists)
RN  - 0 (Methylhistamines)
RN  - 0 (Piperidines)
RN  - 0 (Receptors, Histamine H3)
RN  - 33507-63-0 (Substance P)
RN  - 6986-90-9 (alpha-methylhistamine)
RN  - II4319BWUI (thioperamide)
SB  - IM
MH  - Animals
MH  - Asthma/*metabolism
MH  - Brain/*metabolism
MH  - Guinea Pigs
MH  - Histamine Agonists/pharmacology
MH  - Histamine H3 Antagonists/pharmacology
MH  - Lateral Ventricles
MH  - Male
MH  - Methylhistamines/pharmacology
MH  - Muscle Contraction
MH  - Piperidines/pharmacology
MH  - Receptors, Histamine H3/*metabolism
MH  - Substance P/metabolism
MH  - Trachea/physiopathology
EDAT- 2006/02/01 00:00
MHDA- 2012/06/01 06:00
CRDT- 2010/12/29 06:00
PHST- 2010/12/29 06:00 [entrez]
PHST- 2006/02/01 00:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2006 Feb;22(1):117-21.