PMID- 21186817
OWN - NLM
STAT- MEDLINE
DCOM- 20110504
LR  - 20111117
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 59
IP  - 2
DP  - 2011 Jan 26
TI  - Effects of polyphenolic compounds on tumor necrosis factor-alpha (TNF-alpha)-induced 
      changes of adipokines and oxidative stress in 3T3-L1 adipocytes.
PG  - 546-51
LID - 10.1021/jf1036992 [doi]
AB  - Over the last few decades, obesity has become a global epidemic in both developed 
      and developing countries. Recent studies have indicated that obesity is closely 
      associated with chronic inflammation characterized by abnormal levels of 
      adipocytokines and inflammatory cytokines in adipocytes. The aim of this work was 
      to study the effects of 21 polyphenolic compounds on tumor necrosis factor-alpha 
      (TNF-alpha)-induced changes of adipokines and oxidative stress in 3T3-L1 adipocytes. 
      The results showed that p-coumaric acid, quercetin, and resveratrol have greater 
      inhibition (p < 0.05) of a TNF-alpha-induced increase in the production of 
      interleukin-6 (IL-6) among 21 tested polyphenolic compounds. p-Coumaric acid, 
      quercetin, and resveratrol demonstrated inhibitions of TNF-alpha-induced changes in 
      levels of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator 
      inhibitor-1 (PAI-1), and intracellular reactive oxygen species (ROS) in 3T3-L1 
      adipocytes. Furthermore, p-coumaric acid, quercetin, and resveratrol increased 
      levels (p < 0.05) of secreted adiponectin, superoxide dismutase (SOD), 
      glutathione (GSH), glutathione peroxidase (GPx), and glutathione S-transferase 
      (GST) in TNF-alpha-treated 3T3-L1 adipocytes. These results indicate that the 
      inhibition of TNF-alpha-induced changes of adipokines and oxidative stress by some 
      polyphenolic compounds might have further implications in preventing 
      obesity-related pathologies.
FAU - Yen, Gow-Chin
AU  - Yen GC
AD  - Department of Food Science and Biotechnology, National Chung Hsing University, 
      Taichung 40227, Taiwan.
FAU - Chen, Yi-Chen
AU  - Chen YC
FAU - Chang, Wei-Tang
AU  - Chang WT
FAU - Hsu, Chin-Lin
AU  - Hsu CL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101227
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Adipokines)
RN  - 0 (Flavonoids)
RN  - 0 (Phenols)
RN  - 0 (Polyphenols)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - 3T3-L1 Cells
MH  - Adipocytes/drug effects/*metabolism
MH  - Adipokines/*metabolism
MH  - Animals
MH  - Flavonoids/*pharmacology
MH  - Humans
MH  - Mice
MH  - Obesity/drug therapy/*metabolism
MH  - Oxidative Stress/*drug effects
MH  - Phenols/*pharmacology
MH  - Polyphenols
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2010/12/29 06:00
MHDA- 2011/05/05 06:00
CRDT- 2010/12/29 06:00
PHST- 2010/12/29 06:00 [entrez]
PHST- 2010/12/29 06:00 [pubmed]
PHST- 2011/05/05 06:00 [medline]
AID - 10.1021/jf1036992 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2011 Jan 26;59(2):546-51. doi: 10.1021/jf1036992. Epub 2010 
      Dec 27.