PMID- 21187125
OWN - NLM
STAT- MEDLINE
DCOM- 20110601
LR  - 20140325
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 176
DP  - 2011 Mar 10
TI  - Maternal high-fat intake alters presynaptic regulation of dopamine in the nucleus 
      accumbens and increases motivation for fat rewards in the offspring.
PG  - 225-36
LID - 10.1016/j.neuroscience.2010.12.037 [doi]
AB  - High caloric intake during early postnatal development can have long term 
      consequences for the offspring. We previously reported that the adult offspring 
      of dams fed a high-fat diet during the last week of gestation and throughout 
      lactation display blunted locomotor response to amphetamine (AMP) and reduced 
      sensitization to the drug compared to offspring of control diet dams. Here, we 
      report that the subsensitivity of high-fat offspring to AMP's locomotor stimulant 
      action reflects, at least in part, altered regulation of nucleus accumbens (NAc) 
      dopamine (DA) transmission. When compared to controls, the DA response of 
      high-fat animals to AMP, as measured with microdialysis, was attenuated in the 
      NAc, but unaffected in the prefrontal cortex (PFC). A relatively higher activity 
      of NAc synaptosomal DA transporter sites without changes in vesicular monoamine 
      transporter (VMAT) uptake capacity was also observed in high-fat offspring. 
      Moreover, ventral tegmental area (VTA) D(2) receptor mRNA levels were decreased 
      in high-fat offspring, suggesting a reduction in DA release-regulating D(2) 
      autoreceptors in terminal regions such as the NAc. The magnitude of locomotor 
      response to D(2/3) receptor activation (with quinpirole) was greater in high-fat 
      than in control animals despite having comparable postsynaptic D(2) mRNA levels 
      in the NAc. Finally, while operant responding for a sugar-enriched food reward 
      did not differ between diet groups, high-fat offspring displayed increased 
      operant responding for a fat-enriched reward compared to controls. These findings 
      add to mounting evidence that early life exposure to elevated dietary maternal 
      fat can lead to long lasting changes in DA-mediated behavioral responses to 
      stimulant drugs and fat-enriched foods.
CI  - Copyright (c) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Naef, L
AU  - Naef L
AD  - McGill University, Department of Psychiatry and Douglas Mental Health University 
      Institute, 6875 Lasalle Boulevard, Montreal, Quebec H4H 1R3, Canada.
FAU - Moquin, L
AU  - Moquin L
FAU - Dal Bo, G
AU  - Dal Bo G
FAU - Giros, B
AU  - Giros B
FAU - Gratton, A
AU  - Gratton A
FAU - Walker, C-D
AU  - Walker CD
LA  - eng
GR  - FRN 53350/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101225
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Dietary Fats)
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Receptors, Dopamine)
RN  - 0 (Vesicular Monoamine Transport Proteins)
RN  - CK833KGX7E (Amphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Amphetamine/pharmacology
MH  - Animals
MH  - Brain Chemistry/drug effects
MH  - Chromatography, High Pressure Liquid
MH  - Conditioning, Operant
MH  - Diet
MH  - Dietary Fats/*adverse effects
MH  - Dopamine/analysis/*metabolism
MH  - Dopamine Plasma Membrane Transport Proteins/analysis/metabolism
MH  - Dopamine Uptake Inhibitors/pharmacology
MH  - Female
MH  - In Situ Hybridization
MH  - Male
MH  - Microdialysis
MH  - Motivation/*physiology
MH  - Motor Activity/drug effects/physiology
MH  - Nucleus Accumbens/chemistry/drug effects/*metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine/analysis/metabolism
MH  - Reward
MH  - Synaptic Transmission/drug effects/physiology
MH  - Vesicular Monoamine Transport Proteins/analysis/metabolism
EDAT- 2010/12/29 06:00
MHDA- 2011/06/02 06:00
CRDT- 2010/12/29 06:00
PHST- 2010/10/21 00:00 [received]
PHST- 2010/12/17 00:00 [revised]
PHST- 2010/12/21 00:00 [accepted]
PHST- 2010/12/29 06:00 [entrez]
PHST- 2010/12/29 06:00 [pubmed]
PHST- 2011/06/02 06:00 [medline]
AID - S0306-4522(10)01642-8 [pii]
AID - 10.1016/j.neuroscience.2010.12.037 [doi]
PST - ppublish
SO  - Neuroscience. 2011 Mar 10;176:225-36. doi: 10.1016/j.neuroscience.2010.12.037. 
      Epub 2010 Dec 25.