PMID- 21187363
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20101228
IS  - 1758-1052 (Electronic)
IS  - 0956-4624 (Linking)
VI  - 21
IP  - 11
DP  - 2010 Nov
TI  - Penicillium marneffei infection presenting as an immune reconstitution 
      inflammatory syndrome in an HIV patient.
PG  - 780-2
LID - 10.1258/ijsa.2010.010164 [doi]
AB  - We describe a case of Penicillium marneffei infection acquired in Thailand, 
      manifesting as an immune reconstitution inflammatory syndrome (IRIS) in a 
      Caucasian man with advanced HIV-related immunosuppression (CD4 72 cells/mm(3)). 
      Initial presentation was consistent with Pneumocystis jirovecii pneumonia, and 
      empirical co-trimoxazole resulted in clinical improvement. One month after 
      initiating antiretroviral therapy (ART), an enlarging scaly lesion on his 
      forehead and erythematous nodules on his face, trunk and limbs developed. P. 
      marneffei was isolated from a skin aspirate. Response to antifungal therapy was 
      complicated by drug interactions but cure was complete after four months of 
      treatment. Few cases of IRIS associated with P. marneffei have been reported.
FAU - Ho, A
AU  - Ho A
AD  - The Infection, Tropical Medicine and Counselling Services, Brownlee Centre, 
      Gartnavel General Hospital, Glasgow, UK. antonia.ho@ggc.scot.nhs.uk
FAU - Shankland, G S
AU  - Shankland GS
FAU - Seaton, R A
AU  - Seaton RA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Int J STD AIDS
JT  - International journal of STD & AIDS
JID - 9007917
RN  - 0 (Antifungal Agents)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/immunology/*microbiology
MH  - Adult
MH  - Antifungal Agents/therapeutic use
MH  - Dermatomycoses/drug therapy/immunology/*microbiology/pathology
MH  - Face/microbiology/pathology
MH  - Facial Dermatoses/drug therapy/immunology/*microbiology/pathology
MH  - Forehead/microbiology/pathology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*microbiology
MH  - Male
MH  - Penicillium/*isolation & purification
MH  - Phenotype
MH  - RNA, Viral/blood
MH  - Viral Load
EDAT- 2010/12/29 06:00
MHDA- 2011/05/03 06:00
CRDT- 2010/12/29 06:00
PHST- 2010/12/29 06:00 [entrez]
PHST- 2010/12/29 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
AID - 21/11/780 [pii]
AID - 10.1258/ijsa.2010.010164 [doi]
PST - ppublish
SO  - Int J STD AIDS. 2010 Nov;21(11):780-2. doi: 10.1258/ijsa.2010.010164.