PMID- 21188154
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110708
LR  - 20220408
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Print)
IS  - 1177-5467 (Linking)
VI  - 4
DP  - 2010 Dec 6
TI  - Detection of retinal changes in Parkinson's disease with spectral-domain optical 
      coherence tomography.
PG  - 1427-32
LID - 10.2147/OPTH.S15136 [doi]
AB  - PURPOSE: This pilot study investigated whether high-resolution spectral-domain 
      optical coherence tomography (SD-OCT) could detect differences in inner retinal 
      layer (IRL), peripapillary retinal nerve fiber layer (RNFL), and macular 
      thickness between patients with Parkinson's disease (PD) and controls. METHODS: 
      Both eyes of patients with PD and age-matched controls were imaged with the 
      Heidelberg Spectralis((R)) HRA + OCT. RNFL, IRL, and macular thickness were 
      measured for each eye using Heidelberg software. These measurements were compared 
      with validated, published normal values for macular and RNFL thickness, and 
      compared with matched controls for IRL thickness. RESULTS: Eighteen eyes from 
      nine subjects with PD and 19 eyes of 16 control subjects were evaluated using 
      SD-OCT. The average age of PD patients was 64 years with a range of 52-75 years. 
      The average age of controls was 67 years with a range of 50-81 years. No 
      significant reduction in IRL thickness was detected between PD patients and 
      age-matched controls at 13 points along a 6 mm horizontal section through the 
      fovea. No significant difference in RNFL thickness was detected between PD 
      patients and published normal values. Overall average RNFL thickness was 97 mum 
      for PD patients, which exactly matched the normative database value. However, 
      significant differences in macular thickness were detected in three of nine 
      subfields between PD subjects and published normal values. In PD subjects, the 
      outer superior subfield was 2.8% thinner (P = 0.026), while the outer nasal and 
      inner inferior subfields were 2.8% (P = 0.016) and 2.7% (P = 0.001) thicker 
      compared to published normal values. CONCLUSION: In this pilot study, significant 
      differences in macular thickness were detected in three of nine subfields by 
      SD-OCT. However, SD-OCT did not detect significant reductions in peripapillary 
      RNFL and IRL thickness between PD patients and controls. This suggests that 
      macular thickness measurements by SD-OCT may potentially be used as an objective, 
      noninvasive, and easily quantifiable in vivo biomarker in PD. Larger, 
      longitudinal studies are needed to explore these relationships further.
FAU - Aaker, Grant D
AU  - Aaker GD
AD  - Department of Ophthalmology, Weill Cornell Medical College, New York, NY, USA.
FAU - Myung, Jane S
AU  - Myung JS
FAU - Ehrlich, Joshua R
AU  - Ehrlich JR
FAU - Mohammed, Mujtaba
AU  - Mohammed M
FAU - Henchcliffe, Claire
AU  - Henchcliffe C
FAU - Kiss, Szilard
AU  - Kiss S
LA  - eng
PT  - Journal Article
DEP - 20101206
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC3000768
OTO - NOTNLM
OT  - Parkinson's disease
OT  - inner retinal layer thickness
OT  - macular thickness
OT  - nerve fiber layer thickness
OT  - spectral-domain optical coherence tomography
EDAT- 2010/12/29 06:00
MHDA- 2010/12/29 06:01
PMCR- 2010/12/06
CRDT- 2010/12/29 06:00
PHST- 2010/12/29 06:00 [entrez]
PHST- 2010/12/29 06:00 [pubmed]
PHST- 2010/12/29 06:01 [medline]
PHST- 2010/12/06 00:00 [pmc-release]
AID - opth-4-1427 [pii]
AID - 10.2147/OPTH.S15136 [doi]
PST - epublish
SO  - Clin Ophthalmol. 2010 Dec 6;4:1427-32. doi: 10.2147/OPTH.S15136.