PMID- 21188486
OWN - NLM
STAT- MEDLINE
DCOM- 20111228
LR  - 20231213
IS  - 1573-2592 (Electronic)
IS  - 0271-9142 (Linking)
VI  - 31
IP  - 3
DP  - 2011 Jun
TI  - Expression and functional role of HLA-G in immune cells from patients with 
      systemic lupus erythematosus.
PG  - 369-78
LID - 10.1007/s10875-010-9496-0 [doi]
AB  - Human leukocyte antigen (HLA)-G is a class I non-classical HLA molecule with an 
      important regulatory role on the immune response. The possible role of this 
      molecule in the pathogenesis of SLE has not been explored. In this work, we 
      evaluated the expression and function of HLA-G in SLE patients. We studied 37 SLE 
      patients as well as 25 healthy donors. Peripheral blood monocytes and in 
      vitro-generated dendritic cells (DCs) were analyzed for HLA-G expression by flow 
      cytometry. We found that monocytes from SLE patients as well as mature CD83+ DCs 
      showed a diminished expression of HLA-G compared with healthy controls. In 
      addition, monocytes from SLE patients showed a diminished induction of HLA-G 
      expression in response to stimulation with IL-10. Furthermore, functional assays 
      showed that these monocytes pre-treated with IFN-gamma exhibited a diminished 
      capability to inhibit the proliferation of autologous lymphocytes. Finally, 
      lymphocytes from SLE patients tended to display a lower acquisition of HLA-G (by 
      trogocytosis) from autologous monocytes compared to controls. Our results might 
      have implications for the immune abnormalities observed in patients with SLE.
FAU - Monsivais-Urenda, Adriana Elizabeth
AU  - Monsivais-Urenda AE
AD  - Departamento de Inmunologia, Facultad de Medicina, UASLP, Ave. V. Carranza 2405, 
      78210, San Luis Potosi, SLP, Mexico.
FAU - Baranda, Lourdes
AU  - Baranda L
FAU - Alvarez-Quiroga, Crisol
AU  - Alvarez-Quiroga C
FAU - Abud-Mendoza, Carlos
AU  - Abud-Mendoza C
FAU - Gonzalez-Amaro, Roberto
AU  - Gonzalez-Amaro R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101229
PL  - Netherlands
TA  - J Clin Immunol
JT  - Journal of clinical immunology
JID - 8102137
RN  - 0 (Antigens, CD)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Adult
MH  - Antigens, CD/analysis/immunology
MH  - Case-Control Studies
MH  - Cell Differentiation/drug effects
MH  - Cell Proliferation/drug effects
MH  - Dendritic Cells/immunology/*metabolism/pathology
MH  - Flow Cytometry
MH  - Gene Expression/*immunology
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/immunology/pharmacology
MH  - *HLA-G Antigens/genetics/immunology/metabolism
MH  - Humans
MH  - Immunoglobulins/analysis/immunology
MH  - In Vitro Techniques
MH  - Interferon-gamma/blood/immunology/pharmacology
MH  - Interleukin-10/blood/immunology/pharmacology
MH  - Lupus Erythematosus, Systemic/blood/genetics/*immunology/pathology
MH  - Lymphocyte Activation
MH  - Lymphocytes/immunology/*metabolism/pathology
MH  - Membrane Glycoproteins/analysis/immunology
MH  - Monocytes/immunology/*metabolism/pathology
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
MH  - CD83 Antigen
EDAT- 2010/12/29 06:00
MHDA- 2011/12/29 06:00
CRDT- 2010/12/29 06:00
PHST- 2010/09/08 00:00 [received]
PHST- 2010/12/07 00:00 [accepted]
PHST- 2010/12/29 06:00 [entrez]
PHST- 2010/12/29 06:00 [pubmed]
PHST- 2011/12/29 06:00 [medline]
AID - 10.1007/s10875-010-9496-0 [doi]
PST - ppublish
SO  - J Clin Immunol. 2011 Jun;31(3):369-78. doi: 10.1007/s10875-010-9496-0. Epub 2010 
      Dec 29.