PMID- 21188498
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20110309
IS  - 1573-4927 (Electronic)
IS  - 0006-2928 (Linking)
VI  - 49
IP  - 3-4
DP  - 2011 Apr
TI  - Role of HLA allele polymorphism in chronic hepatitis B virus infection and HBV 
      vaccine sensitivity in patients from eastern Turkey.
PG  - 258-69
LID - 10.1007/s10528-010-9404-6 [doi]
AB  - Human leukocyte antigen (HLA) alleles have been associated with the clinical 
      outcomes of hepatitis B virus (HBV) infection, which range from spontaneous 
      recovery to hepatocellular carcinoma. In this study involving subjects from 
      eastern Turkey, the frequencies of HLA-B35, HLA-CW4, HLA-DQ2, and HLA-DQ8 were 
      markedly higher in the chronic HBV group than those in the spontaneously 
      recovered group; the frequencies of HLA-A11 and HLA-A24 in the nonresponsive HBV 
      vaccine group were markedly higher than those in the responsive HBV vaccine 
      group; and the frequency of HLA-CW6 in the nonresponsive HBV vaccine group was 
      significantly lower than in the responsive group. A complete understanding of HLA 
      types associated with the progression to chronic HBV infection and their effects 
      within the cell at the molecular level will be an important contribution in the 
      development of new HBV vaccines and new treatment strategies for chronic HBV 
      infection.
FAU - Albayrak, Ayse
AU  - Albayrak A
AD  - Department of Infectious Diseases and Clinical Microbiology, Erzurum Region 
      Education and Research Hospital, Erzurum, Turkey. aysealbayrakerz@gmail.com
FAU - Ertek, Mustafa
AU  - Ertek M
FAU - Tasyaran, Mehmet Akin
AU  - Tasyaran MA
FAU - Pirim, Ibrahim
AU  - Pirim I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20101229
PL  - United States
TA  - Biochem Genet
JT  - Biochemical genetics
JID - 0126611
RN  - 0 (HLA Antigens)
RN  - 0 (Hepatitis B Vaccines)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - HLA Antigens/*genetics
MH  - *Hepatitis B Vaccines
MH  - Hepatitis B virus/*immunology
MH  - Hepatitis B, Chronic/*genetics/immunology/prevention & control
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Treatment Outcome
EDAT- 2010/12/29 06:00
MHDA- 2011/06/18 06:00
CRDT- 2010/12/29 06:00
PHST- 2010/02/07 00:00 [received]
PHST- 2010/10/04 00:00 [accepted]
PHST- 2010/12/29 06:00 [entrez]
PHST- 2010/12/29 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - 10.1007/s10528-010-9404-6 [doi]
PST - ppublish
SO  - Biochem Genet. 2011 Apr;49(3-4):258-69. doi: 10.1007/s10528-010-9404-6. Epub 2010 
      Dec 29.